Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The fight against multi-resistant pathogens

28.01.2020

Developing fundamental new approaches against multi-resistant pathogens is the aim of the new Bavarian research network called New Strategies Against Multi-Resistant Pathogens by Means of Digital Networking – bayresq.net. A scientist from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) is also conducting research in an interdisciplinary sub-project in the network, which the State of Bavaria is funding for five years with a total of almost 10 million euros.

Improving our understanding of the immune system


Coordinator of the joint sub-project at FAU and the University of Regensburg, Prof. Dr. Diana Dudziak, Professor of Dendritic Cell Biology at the Department of Dermatology at Universitätsklinikum Erlangen. (Image: FAU/Rudi Ott)

In the fight against multi-resistant bacteria, Prof. Dr. Diana Dudziak, Professor of Dendritic Cell Biology at the Department of Dermatology at Universitätsklinikum Erlangen and coordinator of the project, is conducting research into the immune system of our skin with microbiologists from the University of Regensburg.

Our skin is normally home to bacteria that are important for its function. However, under certain circumstances, these so-called commensal bacteria can develop resistance to antibiotics.

These bacteria can exist on the skin’s surface for several years without any effects. If they enter the body somewhere else through wounds or the use of tubes in a respirator during an operation, it can lead to life-threatening infections.

‘We want to understand more about why our immune system tolerates commensal bacteria such as Staphylococcus epidermis and does not trigger an immune response,’ explains Prof. Dudziak.

To do so, the researchers are investigating the so-called checkpoints the immune system uses to identify bacteria. ‘The aim of the project is to break through this immune tolerance in a targeted manner to facilitate effective immune responses to multi-resistant pathogens,’ explains Prof. Dudziak.

A new research network

‘As a new research network, bayresq.net should make an important contribution to closing a considerable gap in the research and elimination of these pathogens in the long-term’, says Bavarian Science Minister Bernd Siebler.

The participating universities in the six interdisciplinary projects are using the potential of digital methods, for example, to target new types of antibiotics to fight certain pathogens. This adaptation is to be automated using high-throughput approaches and machine learning.

Using big data also makes new approaches possible, such as predictions about the antibiotic resistance and virulence of bacteria through the analysis of the genome. This can facilitate targeted therapies. Each of the six projects has received 1.3 million euros of funding for its research by the State of Bavaria.

Wissenschaftliche Ansprechpartner:

Further information
Prof. Dr. Diana Dudziak
Phone: + 49 9131 8539346
diana.dudziak@uk-erlangen.de

Dr. Susanne Langer | idw - Informationsdienst Wissenschaft
Further information:
https://www.fau.eu/2020/01/23/news/research/the-fight-against-multi-resistant-pathogens/

More articles from Health and Medicine:

nachricht Finding new clues to brain cancer treatment
21.02.2020 | Case Western Reserve University

nachricht UIC researchers find unique organ-specific signature profiles for blood vessel cells
18.02.2020 | University of Illinois at Chicago

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Active droplets

21.02.2020 | Medical Engineering

Finding new clues to brain cancer treatment

21.02.2020 | Health and Medicine

Beyond the brim, Sombrero Galaxy's halo suggests turbulent past

21.02.2020 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>