Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cellular Therapy For Pulmonary Tuberculosis

15.06.2007
Specialists of the Central Scientific Research Institute of Tuberculosis (Russian Academy of Medical Sciences) and the Medical Radiological Research Center (Russian Academy of Medical Sciences) have been developing for three years a treatment mode for pulmonary tuberculosis stable forms.

The mode, on top of traditional complex therapy, includes stem cells intravenous injection to the patient, the stem cells being educed from his/her own marrow (mesenchymal stem cells). Clinical observations have proved that in such a way tubercular process can be stopped with practically incurable patients and their state of health can be improved significantly.

The researchers are studing twenty seven patients with stable forms of pulmonary tuberculosis. Pathogenes of these forms are resistant to the majority of antituberculous drugs, including the most active ones. In essence, these patients feel as the people ill with consumption did in the 19th century. Their lungs gradually decay, and the patients pose constant danger to people around as they excrete mycobacteria - tuberculosis pathogenes. Marrow (mesenchymal) stem cells can restore injured pulmonary tissues and increase patients’ resistivity to infection. They possess the property of differentiating into the cells of bone stock, cartilaginous tissue, adipose tissue and some other tissues – including the cells of healthy respiratory epithelium.

To get the stem cells, the patient underwent sternal puncture or iliac bone puncture. The obtained marrow cells were cultivated, (mesenchymal) stem cells being educed and reproduced in the course of cultivation. Transplantation required 150-200 million cells that were injected intravenously to the patient. In the majority of cases, the procedure did not cause complications, and annoying sensations (moderate temperature, ache, a worn out feeling), if any, were over on the next day. The researchers observed 16 patients for 18 to 24 months, and 11 patients – for at least six months. Within the first five months, all patients felt better: dyspnea reduced, asthenia and indisposition were almost over. Twenty four patients gained weight significantly and noted revitalization and burst of energy. Patients’ indicies of blood noticeably improved.

Three to four months after the transplantation, twenty patients ceased to excrete mycobacteria, this meaning that the active process in the lungs had stopped. According to the tomographic imaging research data, chronic cavities in the pulmonary tissue healed up with 11 patients; cavities in both lungs (that had existed for two years) closed with one of the patients. Inflammatory changes in the lungs dissolved with 15 patients, the lysis cavities partly closed or decreased in size.

At present, 9 patients out of 16, who were injected stem cells 18 to 24 month ago, demonstrate steady remission of tubercular process, the inflammatory changes dissolving and destructive changes disappearing in the lungs, the researchers observed considerable positive dynamics with 6 patients. Only in one case out of 16, the mesenchymal stem cells transplantation effect resulted only in a short-term improvement. The patients who underwent cells transplantation several months ago, continue their treatment, the efficiency of which may be judged 12 to 15 months later.

Although mechanisms of stem cells action are not quite clear yet, the results are promising and they allow to count on new prospects in treatment of stable forms of tuberculosis.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

More articles from Health and Medicine:

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>