What's the secret to living longer? The answer to this age-old question might be found through research looking at neuroendocrine changes throughout the lifespan.
Reporting at the 6th International Congress of Neuroendocrinology (ICN 2006) in Pittsburgh, Polish researchers who studied women aged 20 to 102 suggest a small protein derived from fat tissue may be an important determinant of longevity. Other research indicates boosting growth hormone may allow the elderly to live independently longer. ICN 2006 takes place June 19 – 22 at the David L. Lawrence Convention Center in downtown Pittsburgh.
Summaries of these studies' findings follow:Can stimulating growth hormone delay the physiological effects of aging?
Aging is characterized by a progressive decline in muscle mass, strength and exercise capacity, often leading to frailty and the inability for living independently. Since growth hormone (GH) secretion also declines with age and many age-related changes resemble those seen in GH deficiency, the researchers are investigating the potential physical and endocrine effects of stimulating GH in older adults.
In this controlled trial involving 395 men and women aged 65 to 84 with mild limitations in their physical functioning, participants received either placebo or various oral doses of the growth hormone stimulator (GHS) capromorelin, an investigational medication discovered and developed by Pfizer Global Research and Development. Compared to placebo, GHS at any dose prompted an acute GH peak and an increase in overnight GH secretion – increases that were sustained throughout a 12-month treatment period. The GHS treatment also was associated with a 1.4 Kg increase in lean body (muscle) mass and an improvement in tandem (heel-to-toe) walking at 6 months and in stair climbing at 12 months.
Hormone may hold clue to longevity
A protein derived from fat tissue may be an important determinant of longevity, suggests a study of 133 women, including 25 aged 100 to 102, whom researchers found had notably higher levels of adiponectin circulating in their blood. Adiponectin is a peptide that has anti-inflammatory properties, helps keep vessels clear of fatty deposits and plays an important role in metabolism, particularly of lipids and glucose. Insufficient levels of adiponectin are thought to contribute to obesity, insulin resistance, diabetes or the formation of lipid deposits in the arteries, collectively known as symptoms of metabolic syndrome.
The study, which was conducted by Agnieszka Baranowska-Bik, M.D., and colleagues from the Medical Centre of Postgraduate Education, Warsaw, Poland, looked at blood plasma concentrations of adiponectin in four groups of women: the 25 centenarians, 26 women aged 64 to 67, 45 between the ages of 20 and 43, and 37 obese women aged 26 to 54. Compared to the other groups, the oldest old had significantly higher concentrations of adiponectin as well as much lower levels of both leptin and insulin. Moreover, the oldest-old women scored better with respect to insulin resistance and total cholesterol. Compared to the obese women, who, as expected, had more evidence of metabolic disturbances, the centenarians had significantly fewer signs of hypertension and other symptoms characteristic of metabolic syndrome. Dr. Baranowska-Bik stops short of calling adiponectin the fountain of youth, but the results of this study, she argues, provide evidence that adiponectin may play an important role in longevity.
Held in a different part of the world every four years under the auspices of the International Neuroendocrine Federation, this year's congress – Bridging Neuroscience and Endocrinology – is being sponsored by the American Neuroendocrine Society and the University of Pittsburgh School of Medicine. The first full day of the program, June 20, is being held in conjunction with the 10th Annual Meeting of the Society for Behavioral Neuroendocrinology.
Lisa Rossi | EurekAlert!
Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University
Direct conversion of non-neuronal cells into nerve cells
03.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
17.07.2018 | Information Technology
17.07.2018 | Materials Sciences
17.07.2018 | Power and Electrical Engineering