Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

GM Bacterium Helps Destroy Advanced Tumors in Mice

29.11.2001


Generally speaking, we go to great lengths to rid our bodies of foreign bacteria, whether it’s by brushing our teeth, washing our hands or taking antibiotics. But new research suggests that when it comes to treating tumors, we may one day invite the bugs in. According to a study published yesterday in the early online edition of the Proceedings of the National Academy of Sciences, a bacterium that normally resides in soil, dust and dead flesh quickly destroys large tumors in mice when injected along with chemotherapy drugs.



Current cancer treatments are limited in part by their inability to destroy poorly vascularized areas of tumors: radiation requires oxygen to kill cells and chemotherapy drugs demand a blood system to reach their target. Anaerobic bacteria, on the other hand, actually prefer oxygen-free, or hypoxic, environments. Researchers have thus wondered for some time whether such bacteria might prove useful in combating tumors. Now Bert Vogelstein of Johns Hopkins University and his colleagues have shown that they can be. "The idea is to selectively attack these tumors from inside with the bacteria and from the outside with chemotherapy," Vogelstein explains. The team genetically engineered the bacterium Clostridium novyi, producing a toxin-free strain that, when administered with conventional drugs, eliminated nearly half of the advanced tumors in their lab mice within 24 hours. The healthy tissues surrounding the tumors, in contrast, remained intact.

The team’s so-called combination bacteriolytic therapy (COBALT) did have some negative outcomes, however. As many as 45 percent of the mice with the largest tumors died after treatment, presumably because of toxins released by the deteriorating tumor cells. "Any therapy which dramatically shrinks tumors may be subject to this side effect," the authors note. Yet although such tumor lysis is difficult to control in mice, it may be more easily controlled in humans. Still, whether or not COBALT will even work against human tumors at all remains to be seen. Says team member Kenneth Kinzler: "We hope that this research will add a new dimension to cancer treatment but realize that the way tumors respond to treatment in mice can be different than in humans."

Kate Wong | Scientific American
Further information:
http://www.sciam.com/news/112801/2.html

More articles from Health and Medicine:

nachricht Underwater Snail-o-Bot gets kick from light
27.02.2020 | Max-Planck-Institut für Intelligente Systeme

nachricht Existing drugs may offer a first-line treatment for coronavirus outbreak
27.02.2020 | Norwegian University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: High-pressure scientists in Bayreuth discover promising material for information technology

Researchers at the University of Bayreuth have discovered an unusual material: When cooled down to two degrees Celsius, its crystal structure and electronic properties change abruptly and significantly. In this new state, the distances between iron atoms can be tailored with the help of light beams. This opens up intriguing possibilities for application in the field of information technology. The scientists have presented their discovery in the journal "Angewandte Chemie - International Edition". The new findings are the result of close cooperation with partnering facilities in Augsburg, Dresden, Hamburg, and Moscow.

The material is an unusual form of iron oxide with the formula Fe₅O₆. The researchers produced it at a pressure of 15 gigapascals in a high-pressure laboratory...

Im Focus: From China to the South Pole: Joining forces to solve the neutrino mass puzzle

Study by Mainz physicists indicates that the next generation of neutrino experiments may well find the answer to one of the most pressing issues in neutrino physics

Among the most exciting challenges in modern physics is the identification of the neutrino mass ordering. Physicists from the Cluster of Excellence PRISMA+ at...

Im Focus: Therapies without drugs

Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master.

A study by the Robert Koch Institute has found that one in four women will suffer from weak bladders at some point in their lives. Treatments of this condition...

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

New molten metal hybrid filters from TU Freiberg will make components even safer and more resistant in the future

28.02.2020 | Materials Sciences

Polymers get caught up in love-hate chemistry of oil and water

28.02.2020 | Life Sciences

Two NE tree species can be used in new sustainable building material

28.02.2020 | Architecture and Construction

VideoLinks
Science & Research
Overview of more VideoLinks >>>