A new technology to enable pharmaceutical companies to determine more effectively, and earlier on in clinical trials, whether an experimental drug is toxic to the heart has taken an important step toward the marketplace.
The University of Rochester Medical Center (URMC) and iCardiac Technologies, Inc. have signed an exclusive agreement to commercialize software developed by biomedical engineer Jean-Philippe Couderc, Ph.D., that provides a more accurate and reliable method to analyze data from electrocardiograms (ECG) and other types of heart monitors to determine whether a drug is toxic to the heart.
The technology consists of software known as COMPAS – which stands for Comprehensive Analysis of Repolarization Signal – that allows researchers to target and evaluate specific data produced by ECGs called the QT interval, in addition to other advanced measurements intended to identify specific risks associated with a new drug. The QT interval measures the process of ventricular Repolarization, the period between the heart’s contraction and recovery phase. While the period lasts only a fraction of a second, it represents an important determinant of a drug’s safety.
Mark Michaud | EurekAlert!
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