A systematic review of the evidence for the many drug treatments used in post herpetic neuralgia (the pain that persists after shingles) concludes that long-established treatments such as tricyclic antidepressants and some opioids are as effective as newer drugs such as gabapentin, tramadol, and pregabalin, and supports the use of tricyclic antidepressants as first line treatment. The review, from researchers led by Andrew Rice at Imperial College London, and published in PLoS Medicine in July also found that topical treatments such as lidocaine and capsaicin worked in some patients.
Post herpetic neuralgia is one of a group of chronic pain conditions collectively called "neuropathic pain" that share nerve damage as a common causal factor, and is one of the most frequent diseases used to test new neuropathic pain therapies in clinical trials. The fact that some treatments only worked in selected patients highlights the variety of mechanisms that can cause pain in different patients with post herpetic neuralgia. In the future, before prescribing treatments, doctors might be able to assess the underlying mechanism(s) of each individual patients pain and then tailor treatments accordingly.
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences