Indicates whether infection will develop
Simple analysis of a bone marrow transplant patients oral rinse can give medical personnel a quick indication of the transplants effectiveness and predict whether an infection will develop, says a University of Toronto researcher. Dr. Michael Glogauer, a U of T dentistry professor with the CIHR Group in Matrix Dynamics, Dr. Yigal Dror, a professor at the U of T Faculty of Medicine and a hematologist at the Hospital for Sick Children, and dentistry doctoral candidate Chrissy Cheretakis conducted the study, which received advance online publication this month in Bone Marrow Transplantation. "This test is telling you something you cant yet see in a blood test," says Glogauer, "and we obtained the information simply by having patients rinse their mouths, which is something theyd be doing anyway to counteract the oral mucositis caused by their treatment regimen."
The researchers monitored the oral rinses of 29 pediatric bone marrow transplant patients, testing the basic sodium bicarbonate solutions for the return of neutrophils, specialized white blood cells which fight infection. Their test was able to detect the white blood cells about a week earlier than the blood test which is commonly used to confirm a successful bone marrow transplant.
Dr. Michael Glogauer | EurekAlert!
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