Findings may lead to treatments for hemochromatosis and anemia of chronic disease
A new UCLA and University of Utah study found how a hormone called hepcidin regulates the iron uptake from the diet and its distribution in the body. The study may help develop future treatments for chronic anemia and for diseases of iron overload, such as hemochromatosis. Published online in the journal Science this week, researchers discovered that the hormone hepcidin controls ferroportin, an iron-transporting molecule on the surface of specific cells that contain iron. Hepcidin signals ferroportin not to release iron into the blood stream.
Researchers realized that if there isn’t enough hepcidin to regulate ferroportin, too much iron is taken up from the digestive system into the body, which can lead to hemochromatosis, a major genetic disorder affecting about a million people in the United States. "For the first time we understand what happens in the disease hemochromatosis," said Dr. Tomas Ganz, Ph.D., M.D., one of the study’s principal investigators and professor of medicine and pathology at the David Geffen School of Medicine at UCLA. "We knew that ferroportin is necessary to help release iron into the bloodstream, but didn’t know that hepcidin directly regulates this activity."
Rachel Champeau | EurekAlert!
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
09.11.2018 | Event News
06.11.2018 | Event News
23.10.2018 | Event News
16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences