Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pigment cell transplantation appears helpful for treating patients with stable vitiligo

19.10.2004


Patients with stable vitiligo, a skin disorder characterized by patches of lighter colored, or depigmented skin, may achieve good repigmentation of these areas with skin transplants using skin taken from normally-pigmented areas of their own bodies, according to two articles in the October issue of The Archives of Dermatology, one of the JAMA/Archives journals.



According to the articles, vitiligo is one of the most common pigment cell disorders, distinguished by depigmented patches of skin. Approximately one percent of the world population has vitiligo, whose psychosocial impact is often underestimated, the article states. The standard treatment for vitiligo is ultraviolet (UV) light therapy, which may last several months and can cause physical discomfort. Transplantation of pigment cells (called melanocytes) is another treatment option in patients with vitiligo.

Nanny van Geel, M.D., of Ghent University Hospital, Belgium, and colleagues investigated the efficacy of using transplanted pigment cells to treat 28 patients with vitiligo.


Patients were divided into two groups: patients with stable vitiligo (no new depigmented patches in the past 12 months, n=19) and patients whose vitiligo was not stable (n=9). The researchers selected 33 pairs of depigmented skin patches on the patients- one patch was randomly assigned to be treated with grafted pigment cells, the other was given a sham transplant. Pigment cells were taken from each patient from a site where the skin was normally pigmented. Three weeks after surgery, all patches received UV irradiation therapy twice per week for approximately two months.

The researchers found that there was a significant difference between pigment cell graft sites and placebo graft sites after three, six and 12 months. In patients with stable vitiligo, repigmentation of at least 70 percent of the treated area was achieved in 55 percent, 57 percent, and 77 percent of the actively treated lesions at three, six and twelve months after treatment. In group two, repigmentation of at least 70 percent of the treated area was not achieved at any time point. Repigmentation was diffuse on 94 percent of responding patients. "After a strict preoperative selection for disease stability, transplantation resulted in repigmentation of at least 70 percent of the treated area in most actively treated vitiligo lesions," the authors write.

In another study, Sanjeev V. Mulekar, M.D., of the Noble Clinic, Pune, India investigated the long-term efficacy of skin cell transplantation in 67 patients with vitiligo. Dr. Mulekar used a melanocyte-keratinocyte cell mixture (pigment cells and structural skin cells) taken from normally-pigmented sites on the patients’ own bodies. Patients were followed up for five years.

Dr. Mulekar found that 41 patients (84 percent) with segmental vitiligo (located in a few similar locations on each side of the body, such as around the mouth or on the hands) had 95 percent to 100 percent repigmentation in the treated areas. In patients with focal vitiligo, 73 percent had 95 percent to 100 percent repigmentation in treated areas. These results remained throughout the follow-up period. "Melanocyte-keratinocyte cell transplantation is a simple, safe, and effective surgical therapy," Dr. Mulekar writes. "Patients with segmental and focal vitiligo can experience a prolonged disease-free period, which may extend through the rest of their lives."

Jean Marie Naeyaert | EurekAlert!
Further information:
http://jama.ama-assn.org
http://www.vsnl.com
http://www.medsci.uu.se

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: It’s All in the Mix: Jülich Researchers are Developing Fast-Charging Solid-State Batteries

There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.

The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Quantum bugs, meet your new swatter

20.08.2018 | Information Technology

A novel synthetic antibody enables conditional “protein knockdown” in vertebrates

20.08.2018 | Life Sciences

Metamolds: Molding a mold

20.08.2018 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>