Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Vaccine new treatment for allergies?

27.05.2004


A vaccine against allergies. This may be the eventual result of research at Uppsala university in Sweden. New findings are presented by Anna Ledin in her doctoral dissertation. She vaccinated dogs and rats against their own IgE antibodies, and shows that their allergic symptoms diminished.



The type of antibody called IgE is part of the body’s defense against parasites, but today it is best known for its key role in allergic reactions. IgE is what brings about an allergic reaction. Normally it constitutes 0.02 % of all antibodies in the blood, but people with allergies can have up to ten times as much. The best way for a person with allergies to avoid reactions is to avoid the substance that triggers the allergies. But if you are allergic to pollen it is not easy to avoid all the pollen produced by blossoming birch trees, for example, which can lead to asthma, hay fever, and/or eczema.

Anna Ledin belongs to a team of scientists at Uppsala University that is developing vaccines against allergies, under the direction of Professor Lars Hellman. Her dissertation is part of this project. She presents a new form of treatment for allergies in her study. By producing and injecting an IgE vaccine that looks like IgE, she demonstrates that the body perceives the vaccine as something alien. Antibodies are then produced to fight both IgE and the vaccine, bringing down the levels of IgE in the blood and reducing the allergic symptoms. The allergy vaccine has been tested on rats and dogs, and the results indicate a clear reduction of IgE levels after vaccination. Dogs are one of the few animals that have allergic reactions like humans, but it has been unclear just how IgE levels are related to their symptoms. A new method for monitoring IgE levels in the blood of dogs was developed by the research team, and it was found that dogs have extremely high levels of IgE, regardless of whether they were healthy or had allergic eczema, autoimmune disorders, or skin parasites. This makes it problematic to diagnose allergies merely on the basis of IgE from dog blood. What’s more, IgE was measured from three sets of puppies, and, unlike mature dogs, the puppies evinced low levels of IgE.


What causes allergies then? It is certain that both environmental and genetic factors play a role. But it has not been determined exactly which genes are involved or to what extent they are involved. Therefore Anna Ledin and the research team examined how a part of one chromosome, containing many different genes, is involved in the regulation of IgE in rats. That particular chromosomal region has previously been implicated in the susceptibility of rats to developing pain in their joints in a model for arthritic rheumatism, and they found that it also affects IgE levels in rats. It remains to be studied whether this chromosomal region also impacts IgE levels in humans.

Anneli Waara | alfa
Further information:
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4254

More articles from Health and Medicine:

nachricht Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

Im Focus: Topological material switched off and on for the first time

Key advance for future topological transistors

Over the last decade, there has been much excitement about the discovery, recognised by the Nobel Prize in Physics only two years ago, that there are two types...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Data use draining your battery? Tiny device to speed up memory while also saving power

14.12.2018 | Power and Electrical Engineering

Tangled magnetic fields power cosmic particle accelerators

14.12.2018 | Physics and Astronomy

In search of missing worlds, Hubble finds a fast evaporating exoplanet

14.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>