Patients with inflammatory diseases such as arthritis, chronic infections and some types of cancer, often become anemic – a condition called anemia of chronic disease (ACD). While ACD rarely kills patients, it can make their lives miserable. A discovery at EMBL, in collaboration with researchers at Children’s Hospital Boston and Harvard Medical School, now links the gene HFE to ACD. The HFE gene is mutated in patients suffering from the common iron overload disease hemochromatosis. This finding gives hope that one day an effective and specific therapy may be developed to treat ACD (featured in Nature Genetics, April 18, 2004).
When people are infected with microbes, the level of iron in their blood drops. This has an important function: iron is essential for the growth of infectious microbes, so one way for the body to fight back is to lower the amount of iron in circulation.
“Unfortunately, while this decrease in iron hinders the spread of parasites and is beneficial in the short term, it can cause anemia," notes EMBL Group Leader Matthias Hentze. “During a long term inflammatory condition, low levels of iron can starve the bone marrow of this metal which is essential for blood cells, leading to ACD.”
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Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
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When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
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