Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gliomas’ ’molecular fingerprint’ predicts how aggressive tumor will be

20.11.2003


Findings may help tailor treatment decisions for most common form of brain tumor



The most common form of primary brain tumor – glioma, affecting about 25,000 Americans each year – poses a dilemma for doctors and patients trying to make decisions about treatment. Many of these tumors will be particularly vicious, killing patients within months of diagnosis even in the face of the most vigorous therapy. Still others are less aggressive, but these can be difficult to distinguish under the microscope.

Now, scientists at the Vanderbilt-Ingram Cancer Center and the National Institutes of Health demonstrate that the "molecular fingerprint," or protein patterns, of gliomas can be used to classify tumors and predict their aggressiveness.


"This study is important because we show that the ’molecular fingerprint’ of the tumor can be used to assess the progression of disease and more importantly predict how aggressively it will behave," said Richard Caprioli, Ph.D., Stanley Cohen Professor of Biochemistry at Vanderbilt. "This is the necessary step toward the goal of predictive medicine, where clinicians would analyze an individual’s tumor, scientifically predict how it will behave and use that information to tailor treatment decisions," Findings by Caprioli and his colleagues are being reported today in Boston at the annual International Molecular Targets and Cancer Therapeutics: Discovery, Biology and Clinical Application," a meeting organized by the American Association for Cancer Research (AACR), the National Cancer Institute (NCI) and the European Organization for Research and Treatment of Cancer (EORTC).

The conference brings together 2,500 scientists and clinicians to share the latest information in the field known as molecular targeting, which offers the potential of a new generation of drugs to kill cancer cells with pinpoint accuracy.

Caprioli’s co-authors on the abstract include Dr. Robert J. Weil, formerly a Vanderbilt faculty member now with the National Institutes of Health, and Vanderbilt scientists Sarah A. Schwartz, Bill White, Juiming Li, Jason Moore, Bashar Shaktour, Paul Larsen and Yu Shyr.

The field of molecular targeting in cancer focuses on the proteins that are active in cells and involved in the development and spread of the disease. Simply put, proteins carry out al the work of the cell, at the instruction of the genes. Disease can occur when the intricate interplay of thousands of proteins goes awry; the goal of molecularly targeted therapy is to set the process right again in a way that specifically corrects the problem without causing damage to surrounding normal cells.

Using a process developed by Caprioli and refined for clinical application at Vanderbilt, the researchers used mass spectrometry to develop profiles of proteins active in 60 human brain samples. These included 19 samples of normal tissue and 15 grade II, 11 grade III and 15 grade IV gliomas.

The researchers identified more than 200 potential molecular markers that distinguished normal from malignant tissue and differentiated grade of tumor. With these protein profiles, they were also able to group tumors – with approximately 90 percent accuracy -- according to survival rate (15 biopsies from patients who survived less than one year and 26 from patients who survived more than one year).

"We want to be able to provide patients with a complete picture of how their tumor is expected to behave and how it is expected to respond to treatment," Caprioli said. "Then they an their doctors can make a truly informed decision, based in science, about how to treat or even whether to treat. Clinicians would be able to aggressively treat those cancers that are truly aggressive and in those that are not, avoid such powerful treatment and exposing patients to more risk than necessary." Caprioli and his colleagues have done similar work in lung cancer. Earlier this year, they reported identification of a specific pattern of 15 proteins that could be used to predict whether a group of patients would die within a year of diagnosis. That work was published in the journal Lancet.


The Vanderbilt-Ingram Cancer Center is the only National Cancer Institute-designated Comprehensive Cancer Center in Tennessee and one of only 39 in the United States. This designation is the highest awarded by the NCI, one of the National Institutes of Health and a leading authority on cancer. It recognizes excellence in all aspects of cancer research, the development of innovative new therapies and a demonstrated commitment to the community through education, information and outreach.

Cynthia Floyd Manley | EurekAlert!
Further information:
http://www.mc.vanderbilt.edu/reporter/
http://www.vicc.org

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Metal too 'gummy' to cut? Draw on it with a Sharpie or glue stick, science says

19.07.2018 | Materials Sciences

NSF-supported researchers to present new results on hurricanes and other extreme events

19.07.2018 | Earth Sciences

Scientists uncover the role of a protein in production & survival of myelin-forming cells

19.07.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>