Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cervical cancer screening

04.11.2003


No proven benefit of detection of human papillomavirus alone compared with the conventional Pap smear

Under the aegis of the French Society of Clinical Cytology, physicians at the Institut Curie have evaluated the relevance of the papillomavirus detection test, Hybrid Capture‚ II, in screening for cervical cancer, the second most common cancer in women worldwide. They have shown that this test cannot replace cytological analysis of the cervical smear.
For the first time a learned society, the French Society of Clinical Cytology, has organized a multicenter, national study in general practice. Cervical cancer screening is one of 70 priority measures in France’s Cancer Plan, and an important goal is to establish a test that combines reliability, feasibility and affordability. This work was published in the October 2003 issue of the American Journal of Clinical Pathology.


Cervical cancer is the second most common cancer in women, with 465 000 new cases and 200 000 deaths worldwide every year. In France, 3 387 new cases and 1 000 deaths were recorded in 2000. Cervical cancer affects women in all age ranges, from 25 years upwards.

Cervical cancer screening: a national priority

Early detection of cervical cancer through intensified screening is one of the 70 measures of the Cancer Plan launched in France by the President of the Republic. Screening is based on the cervical smear test. In this simple and painless test, cells are collected from the surface of the cervix and are examined under the microscope for any anomaly suggestive of lesions that are precancerous or cancerous. It should be performed every three years.

The Cancer Plan is intended to broaden availability of the smear test (family planning, occupational medicine...) to women who do not have a gynecologist, so as to intensify information actions and facilitate testing for papillomavirus infection.
In France, generalization of the smear test has already led to a reduction in the incidence of cervical cancer: the number of cases decreased from 5 992 in 1975 to 3 387 in 2000, i.e. a 46 % decrease in 25 years.

This incidence though is still high, possibly due to the fact that the female population is not fully covered and also because some women develop cervical cancer despite regular smear tests, which clearly have shortcomings (false-negatives, absence of abnormal cells in the area of the smear…). Screening should be improved by the implementation of more sensitive tests.

Comparison of detection of HPV and cytologic analysis

Close to 90% of cervical cancers develop from pre-invasive lesions due to a human papillomavirus (HPV). The efficiency of screening could be improved by the inclusion of testing for HPV.

Under the aegis of the French Society of Clinical Cytology, physicians of the Institut Curie, coordinated by Dr Béatrix Cochand-Priollet (1) have evaluated the efficiency and relevance of the Hybrid Capture‚ II papillomavirus DNA test (HC-II) (2). This test performed on the cervical smear detects papillomavirus DNA and distinguishes high-risk from low-risk HPVs.

By comparing cytologic analyses and the HC-II test in 1 785 patients, the Institut Curie physicians have shown that the HC-II test performed alone is less sensitive than cytologic analysis of a cervical smear.

In conclusion, comparative analysis of the sensitivity and specificity of the HC-II technique and of the conventional Pap smear reveals no advantage of HPV detection alone in the framework of cervical cancer screening.

It is therefore unlikely that the HC-II test will replace cytologic analysis, but it could in certain cases be complementary. Further studies are needed to define the role of the HC-II test in cervical cancer screening and follow-up.


Note

(1) Dr Béatrix Cochand-Priollet works in the Pathological Anatomy and Cytology Department of the Hôpital Lariboisière.
(2) This test is manufactured by Digene“ (Gaithersburg, USA).

Catherine Goupillon | Institut Curie

More articles from Health and Medicine:

nachricht Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen

nachricht Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>