Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Role in Type 1 diabetes provides clue for researchers who discovered ’obesity gene’

04.11.2003


The discovery of a gene believed to be connected to morbid obesity has international origins and began as an exploration into the causes of Type I diabetes.



The discovery, which will be published in an upcoming issue of the journal Public Library of Science (http://www.plos.org), involves researchers originally from Sweden and France who collaborated at the University of Washington in Seattle.

The gene, on Chromosome 10, was first connected to diabetes in 1991 by Dr. Åke Lernmark, R. H. Williams Professor of Medicine and adjunct professor of immunology at the UW. The GAD2 gene is responsible for the protein GAD65, which plays a role in the healthy use of insulin by the body. Lernmark is a native of Sweden, which has one of the highest rates of Type I diabetes incidence in the world.


Lernmark is a native of Sweden, which has one of the highest rates of Type I diabetes incidence in the world. In 1997, Lernmark was joined in his laboratory at the University of Washington by Professor Philippe Froguel as a Poll Visiting Scholar.*

Froguel, senior author of the research, is based at Imperial College London, and Hammersmith Hospital, London, and carried out the research while at the Institut Pasteur de Lille in France. Froguel and colleagues had previously determined that obese people often had genetic variations in Chromosome 10, with individual variations showing up in the GAD2 gene.

During and since the stay at the Lernmark lab, the researchers have collaborated ever since the GAD2 gene was first considered as a candidate obesity gene. The researchers believe that GAD2 produces the protein GAD65 that catalyzes the production of a neurotransmitter in the hypothalamus that stimulates or suppresses appetite.

Lermark says that several years ago, he and his colleagues in Sweden found that some obese people had antibodies to GAD65. This finding remained unexplained, but sparked Froguel’s interest when he was searching chromosome 10 for an obesity gene candidate. Lernmark says that it was a pleasant surprise for both groups when it turned out that GAD2 gene was the candidate. Research may help to untangle the role of GAD65 in obesity, he said.

Froguel and colleagues screened 575 obese people and 646 non-obese people in France and found a connection between variations in the GAD2 gene and obesity.

Obese people with two particular variations in their GAD2 genes had more difficulty controlling food intake as measured by a standard survey of eating behavior.

Lernmark, a co-author, cautions that researchers are very far from any genetic treatment of obesity. He says obesity results from the interaction of a variety of genes and environmental factors, such as nutrient intake and physical activity. Lernmark said he hopes there will be further research on genetic connections to obesity, and further work to pinpoint the underlying biology of body weight control and eating behavior. Meanwhile, research continues in the Lernmark lab and in other labs across the country about the effect of GAD2 on diabetes.


###
* The Poll Visiting Scholar Program

The Harvey and Judy Poll Visiting Scholar Endowment was established at the University of Washington in 1990 through the generous support of Harvey and Judy Poll, who have a long-standing interest in diabetes research. The endowment makes it possible to invite distinguished scholars in the field of diabetes research to the University of Washington, fostering new research collaborations with diabetes investigators throughout the world.

Walter Neary | EurekAlert!
Further information:
http://www.washington.edu/
http://www.plos.org

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>