A team led by researchers at Washington University School of Medicine in St. Louis, in collaboration with researchers at Eli Lilly and Co. in Indianapolis, have developed a new technique that, for the first time, provides a way to dynamically study proteins known to be related to Alzheimers disease in the fluid between brain cells, called interstitial fluid.
Using this new technique in mice, the team discovered that the relationship between levels of a key molecule involved in Alzheimers disease, amyloid-beta (ABeta), in interstitial fluid and cerebrospinal fluid changes as the disease progresses. Cerebrospinal fluid -– the fluid that cushions and surrounds the brain – is a main focus in efforts to diagnose and possibly treat Alzheimers disease.
"The most exciting part of this study is that we now have a way to measure a pool of ABeta that previously could not be evaluated," says John R. Cirrito, a graduate student in neuroscience. "Using this new approach, we were able to identify another difference between young mice that have not yet developed Alzheimers-like changes and those that have developed Alzheimers-like brain changes, which provides a new opportunity to explore the development of this disease."
Gila Z. Reckess | EurekAlert!
Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University
Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences