A team led by researchers at Washington University School of Medicine in St. Louis, in collaboration with researchers at Eli Lilly and Co. in Indianapolis, have developed a new technique that, for the first time, provides a way to dynamically study proteins known to be related to Alzheimers disease in the fluid between brain cells, called interstitial fluid.
Using this new technique in mice, the team discovered that the relationship between levels of a key molecule involved in Alzheimers disease, amyloid-beta (ABeta), in interstitial fluid and cerebrospinal fluid changes as the disease progresses. Cerebrospinal fluid -– the fluid that cushions and surrounds the brain – is a main focus in efforts to diagnose and possibly treat Alzheimers disease.
"The most exciting part of this study is that we now have a way to measure a pool of ABeta that previously could not be evaluated," says John R. Cirrito, a graduate student in neuroscience. "Using this new approach, we were able to identify another difference between young mice that have not yet developed Alzheimers-like changes and those that have developed Alzheimers-like brain changes, which provides a new opportunity to explore the development of this disease."
Gila Z. Reckess | EurekAlert!
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