Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Epitope plays a key role in the development of rheumatoid arthritis

16.07.2003


Rheumatoid arthritis is a chronic inflammatory disease characterized by joint destruction. It has been suggested that the extracellular matrix protein osteopontin (OPN), which is expressed by a number of different mediators of the immune response, may facilitate this destruction.



In the July 15 issue of The Journal of Clinical Investigation, Nobuchika Yamamoto and colleagues from the Fujisawa Pharmaceutical Company in Japan, provide important new evidence indicating a role for OPN in the pathogenesis of inflammatory arthritis and associated joint destruction.

OPN is abundant in bone, where it facilitates cell adhesion and modulation of the immune response. This adhesion is facilitated by interaction with a variety of cell surface molecules known as integrins. Binding of OPN to these cell surface molecules generally occurs at a specific integrin-binding motif. A second sequence, (SLAYGLR in mice and SVVYGLR in humans) within OPN has also been shown to mediate this cell adhesion. The site is the result of cleavage of human OPN by the protease thrombin and promotes the adherence of cells expressing intergrins a4 and a9.


In their latest report, Yamamoto and colleagues observed that monocytes of arthritic mice had a greater tendency to migrate toward thrombin-cleaved OPN, than full-length OPN, and that these monocytes expressed integrins a4 and a9 that bind the SLAYGLR epitope. Furthermore, the authors demonstrated that antibody blockade of the SLAYGLR sequence stopped monocyte migration to the cleaved OPN and significantly suppressed the development of arthritis in mice. The study indicates the critical role of the SLAYGLR sequence in the pathogenesis of rheumatoid arthritis in mice.

"The effects on the clinical and histologic parameters studied provide convincing additional evidence for a role of OPN in arthritic inflammation, and specifically in the recruitment of inflammatory cells to arthritic joints" stated Dr. Ellen Gravallese from Beth Israel Deaconess Medical Center and Harvard Institutes of Medicine in her accompanying commentary. She continues "given the clear and important role of OPN in inflammatory processes and bone remodeling, it will be of considerable interest to resolve some of the remaining controversies regarding the role of OPN in this disease".

Contact:

Nobuchika Yamamoto
Exploratory Research Laboratories,
Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Phone: 81-029-847-8611
Fax: 81-029-847-1536
Email: nobuchika_yamamoto@po.fujisawa.co.jp

Brooke Grindlinger | EurekAlert!
Further information:
http://www.jci.org

More articles from Health and Medicine:

nachricht Deep stimulation improves cognitive control by augmenting brain rhythms
04.04.2019 | Picower Institute at MIT

nachricht Black nanoparticles slow the growth of tumors
04.04.2019 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

Im Focus: A long-distance relationship in femtoseconds

Physicists observe how electron-hole pairs drift apart at ultrafast speed, but still remain strongly bound.

Modern electronics relies on ultrafast charge motion on ever shorter length scales. Physicists from Regensburg and Gothenburg have now succeeded in resolving a...

Im Focus: Researchers 3D print metamaterials with novel optical properties

Engineers create novel optical devices, including a moth eye-inspired omnidirectional microwave antenna

A team of engineers at Tufts University has developed a series of 3D printed metamaterials with unique microwave or optical properties that go beyond what is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

New automated biological-sample analysis systems to accelerate disease detection

18.04.2019 | Life Sciences

Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

18.04.2019 | Physics and Astronomy

New eDNA technology used to quickly assess coral reefs

18.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>