Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New approach to replacing immune cells shrink tumors in patients with melanoma

20.09.2002


A new approach to cancer treatment that replaces a patient’s immune system with cancer-fighting cells can lead to tumor shrinkage, researchers report today in the journal Science*. The study demonstrates that immune cells, activated in the laboratory against patients’ tumors and then administered to those patients, can attack cancer cells in the body.



The experimental technique, known as adoptive transfer, has shown promising results in patients with metastatic melanoma who have not responded to standard treatment. With further research, scientists hope this approach may have applications to many cancer types, as well as infectious diseases such as AIDS.

In the study, 13 patients with metastatic melanoma (a deadly form of skin cancer) who had not responded to standard treatments were treated with immune cells produced in the laboratory specifically to destroy their tumors. The treatment resulted in at least 50 percent tumor shrinkage in six of the patients, with no growth or appearance of new tumors. Four additional patients had some cancer growths disappear.


Researchers have tried previously to treat cancer with immune cells but the cells did not survive well in the body. "In the past, only a fraction of a percent of the cells we injected were able to survive, and they would persist for only a few days," said Steven A. Rosenberg, M.D., Ph.D., of the National Cancer Institute, the lead researcher on the study.

Improvements in the way immune cells are generated in the laboratory and the way patients’ bodies are prepared to receive them, however, have led to dramatically different results. "We have been able to generate a very large number of immune cells that appear in the blood and constitute a majority of the immune system of the patient. These persist for over four months and are able to attack the tumor," Rosenberg said.

The adoptive transfer technique fights cancer with T cells, immune cells that recognize and kill foreign cells that have invaded the body. Researchers used a small fragment of each patient’s melanoma tumor to grow T cells in the laboratory, using T cells originally taken from the patients. Exposure to the tumor activated the immune cells so that they would recognize and attack cells from each specific cancer.

Once the T cells had multiplied to a sufficient number to be used for treatment, they were administered to patients. Patients were also given a high dose of a protein called interleukin-2 (IL-2), which stimulates continued T cell growth in the body. Prior to the immunotherapy, chemotherapy had been used to deplete patients’ own immune cells, which had proven ineffective at fighting the cancer. Diminishing the old cells provided an opportunity for the new T cells to repopulate patients’ immune systems. Analysis of blood and tumor samples from many of the patients who responded favorably to the treatment revealed that the administered immune cells were thriving, multiplying rapidly, and attacking tumor tissue. T cells activated against melanoma became the major component in patients’ immune systems. They persisted for several months and were able to destroy metastases throughout the body.

Over time, patients’ old immune systems recovered, restoring their ability to fight infections. Researchers report that among the patients in the study, only occasional opportunistic infections developed during treatment.

Other side effects were mild autoimmune disorders. T cells act by recognizing a protein fragment called an antigen on the outside of the tumor cells. Antigens found on tumor cells may also be found on certain normal cells in the body, making them vulnerable to attack. Autoimmune effects among the patients in the study were mild and easily controlled.

Although the treatment is highly experimental, researchers are optimistic that it may, in the future, extend beyond the treatment of patients with melanoma. It should be possible, they say, to raise immune cells that will recognize and attack many tumor types.

Similarly, the same technique could potentially be used to treat some infectious diseases, such as AIDS.

NCI Press Office | EurekAlert!
Further information:
http://www.cancer.gov

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>