Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rutgers research shows caffeine may prevent skin cancer

27.08.2002


Treating the skin with caffeine has been shown to prevent skin cancer in laboratory studies conducted in the Susan Lehman Cullman Laboratory for Cancer Research at Rutgers, The State University of New Jersey.



"It is not a sun-screening effect, but it’s something more than that – it’s a biological effect," said Allan Conney, William M. and Myrle W. Garbe Professor of Cancer and Leukemia Research at Rutgers’ Ernest Mario School of Pharmacy. "We may have found a safe and effective way of preventing skin cancer," he said of the discovery, described in the Proceedings of the National Academy of Sciences early online edition, available the week of Aug. 26.

It has been known for a long time that skin cancer is caused predominantly by sunlight. The authors, a group that included Conney and a team of other researchers in the laboratory, explained that sunscreen use has decreased the risk of skin cancers, but there is a need to identify additional approaches for skin-cancer prevention in individuals previously exposed to high-dose levels of sunlight.


The research team, all members of the school’s department of chemical biology, studied a special strain of hairless mice that had been exposed to ultraviolet B light twice weekly for 20 weeks. This put the mice at risk for tumor formation and skin cancer. After stopping the exposures, the researchers applied caffeine and epigallocatechin gallate (EGCG), two components of green tea, topically to the skin. Both caffeine and EGCG significantly inhibited cancer formation in the mice.

Although the study showed that most of the positive effects were true for both of these substances, caffeine has the advantage over EGCG. EGCG is chemically less stable, so there could be a problem in applying it topically, Conney said A previous study conducted in the laboratory dealt with caffeine taken orally. The caffeine was provided in the drinking fluid for the mice and the researchers found it inhibited ultraviolet light-induced tumors and cancers in this case, as well. Conney cites advantages to using the direct skin application over oral administration, pointing to the ability to provide more highly concentrated doses and larger overall dosages. "Whether you can give enough orally to be effective in humans is not known," said Conney. "Whether people could ingest that amount without becoming hyperactive is also a real question mark."

The newly published study also reported the highly selective action of both caffeine and EGCG in killing cancer cells. Adjacent normal skin cells were not affected. "The discovery of this selectivity was very exciting to us," said Conney. "Also, in our study it didn’t matter if the tumors were benign or malignant; cells in both were killed while leaving the normal cells alone."

The study suggests further research is needed to determine whether or not the skin application of these agents would be effective in people. The researchers anticipate human clinical trials in the near future. "For now," said Conney, "if you are a mouse, it would be terrific. In people we just don’t know yet."

Joseph Blumberg | EurekAlert!
Further information:
http://www.rutgers.edu/

More articles from Health and Medicine:

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Massive impact crater from a kilometer-wide iron meteorite discovered in Greenland

15.11.2018 | Earth Sciences

When electric fields make spins swirl

15.11.2018 | Physics and Astronomy

Discovery of a cool super-Earth

15.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>