The porous glass, originally developed at Imperial College is capable of acting as an active template for new bone growth, dissolving in the body without leaving any trace of itself or any toxic chemicals. As it dissolves it releases calcium and other elements such as silicon into the adjacent body fluids, stimulating bone growth.
The glass activates genes present in human bone cells which encode proteins controlling the bone cell cycle and the differentiation of the cell to form bone matrix and rapid mineralisation of bone nodules. It is the release of soluble silica and calcium ions in specific concentrations that activate the genes. Gene activation occurs only when the timing sequence of the cell cycle is matched by that of the glass surface reactions and controlled release of the ions.
Partners at the Universities of Kent and Warwick have been carrying out experiments at the Science and Technology Facilities Council’s world leading ISIS neutron source. Research at ISIS is showing exactly how the calcium is held in the glass and thereby precisely how it is released into the body. Professor Bob Newport at the University of Kent explains that it was when the material was studied at ISIS that the process became clear.
“Although variants of these bioactive materials are already in clinical use, and the role of calcium in these materials was already understood as being critical in terms of both the stability of the glass and its bioactivity, no direct and quantitative study of the calcium atoms within the glass network had been undertaken. Using ISIS to study the relationship between these atoms and the host silicate glass via techniques unique to neutron diffraction has enabled us to move forward with the programme. The key outcome of our experiments has been a full understanding, at the level of atomic arrangements, of why it is that calcium is able so easily to leave the glass at the rate required to generate the desired response.”
By comparing samples made with natural calcium and with a calcium isotope it was possible for the first time to isolate the complex and subtle contribution of the calcium from that of all the other atoms present.
Dr Andrew Taylor, Director of the ISIS neutron source commented, “To allow people to remain active, and to contribute to society for longer, the need for new materials to replace and repair worn out and damaged tissues becomes ever more important. We’re pleased that at ISIS we can continue to contribute to cutting edge research that affects all our lives.”
Natalie Bealing | alfa
New nanomedicine slips through the cracks
24.04.2019 | University of Tokyo
Sugar entering the brain during septic shock causes memory loss
23.04.2019 | Rensselaer Polytechnic Institute
Flexible, organic and printed electronics conquer everyday life. The forecasts for growth promise increasing markets and opportunities for the industry. In Europe, top institutions and companies are engaged in research and further development of these technologies for tomorrow's markets and applications. However, access by SMEs is difficult. The European project SmartEEs - Smart Emerging Electronics Servicing works on the establishment of a European innovation network, which supports both the access to competences as well as the support of the enterprises with the assumption of innovations and the progress up to the commercialization.
It surrounds us and almost unconsciously accompanies us through everyday life - printed electronics. It starts with smart labels or RFID tags in clothing, we...
The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.
Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.
Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.
Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...
A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter
A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.
Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...
17.04.2019 | Event News
15.04.2019 | Event News
09.04.2019 | Event News
25.04.2019 | Materials Sciences
25.04.2019 | Earth Sciences
25.04.2019 | Life Sciences