Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

European membrane expertise to focus on new treatments for human diseases

18.03.2008
A new 15 million Euro project led by the University of Leeds aims to find novel treatments for many human diseases by bringing together the leading European experts in membrane proteins.

The project – the European Drug Initiative for Channels and Transporters (EDICT) – will target about 80 proteins, which play an important role in human diseases as varied as diabetes, heart disease, neuropsychiatric disorders like epilepsy and depression, osteoporosis, stomach ulcers and cataracts.

Membrane proteins are key to every process in the human body, channelling ions or transporting chemicals and so are ideal targets for new treatments. Infections by pathogenic bacteria, yeasts and parasites also involve their own membrane proteins, which can be specific targets for development of new drugs and antibiotics.

The research is mainly funded by the European Commission, involves twenty-seven partners from twelve countries – including two Nobel Laureates - and is set to last four years.

Coordinating the project is Peter Henderson, Professor of Biochemistry and Molecular Biology from Leeds’ Faculty of Biological Sciences.

“Membrane proteins are seen by many as the next potential source of drug development, and so the EC is keen to fund research in this area,” he said. “However, they are difficult to study and are poorly understood, though the recent sequencing of the human and other genomes show they make up about one third of all proteins in all organisms, including humans.”

“At the moment, few groups of membrane proteins are being seriously investigated by the pharmaceutical industry, so this project will help to fill that gap. By bringing together the best scientists in this challenging field from all over Europe, we hope to make a real advance towards new treatments for key diseases.”

Industry has also seen the benefit of bringing such expertise together under one umbrella and working with the academics will be pharmaceutical giant AstraZeneca and a smaller company, Xention, which specialises in the discovery and development of novel and selective ion channel drugs.

The researchers include biologists, structural biologists, chemists and experts in the three key technologies: x-ray crystallography, nuclear magnetic resonance, and electron microscopy.

The team aims to map out the structure of the proteins, so they can identify compounds that could be developed as a treatment for these diseases. Where they have already mapped some structures, the team will have a head start and hope to make real advances towards new treatments.

Other researchers joining the project from Leeds include Professors Steve Baldwin and Carola Hunte from the Faculty of Biological Sciences and Professor Peter Johnson and Dr Colin Fishwick from the School of Chemistry. All are members of Leeds’ Astbury Centre, the leading interdisciplinary research centre in the UK studying how life works at an atomic level.

The two Nobel Laureates involved in the research are Director of the Medical Research Council’s Dunn Human Nutrition Unit in Cambridge, Professor Sir John Walker, who also holds an honorary doctorate from the University of Leeds, and Director of the Max Planck Institute for Biophysics in Frankfurt, Germany, Professor Hartmut Michel.

Jo Kelly | alfa
Further information:
http://www.leeds.ac.uk/media

More articles from Health and Medicine:

nachricht Discovery shows promise for treating Huntington's Disease
05.08.2020 | Ecole Polytechnique Fédérale de Lausanne

nachricht Carbon monoxide improves endurance performance
05.08.2020 | Universität Bayreuth

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: ScanCut project completed: laser cutting enables more intricate plug connector designs

Scientists at the Fraunhofer Institute for Laser Technology ILT have come up with a striking new addition to contact stamping technologies in the ERDF research project ScanCut. In collaboration with industry partners from North Rhine-Westphalia, the Aachen-based team of researchers developed a hybrid manufacturing process for the laser cutting of thin-walled metal strips. This new process makes it possible to fabricate even the tiniest details of contact parts in an eco-friendly, high-precision and efficient manner.

Plug connectors are tiny and, at first glance, unremarkable – yet modern vehicles would be unable to function without them. Several thousand plug connectors...

Im Focus: New Strategy Against Osteoporosis

An international research team has found a new approach that may be able to reduce bone loss in osteoporosis and maintain bone health.

Osteoporosis is the most common age-related bone disease which affects hundreds of millions of individuals worldwide. It is estimated that one in three women...

Im Focus: AI & single-cell genomics

New software predicts cell fate

Traditional single-cell sequencing methods help to reveal insights about cellular differences and functions - but they do this with static snapshots only...

Im Focus: TU Graz Researchers synthesize nanoparticles tailored for special applications

“Core-shell” clusters pave the way for new efficient nanomaterials that make catalysts, magnetic and laser sensors or measuring devices for detecting electromagnetic radiation more efficient.

Whether in innovative high-tech materials, more powerful computer chips, pharmaceuticals or in the field of renewable energies, nanoparticles – smallest...

Im Focus: Tailored light inspired by nature

An international research team with Prof. Cornelia Denz from the Institute of Applied Physics at the University of Münster develop for the first time light fields using caustics that do not change during propagation. With the new method, the physicists cleverly exploit light structures that can be seen in rainbows or when light is transmitted through drinking glasses.

Modern applications as high resolution microsopy or micro- or nanoscale material processing require customized laser beams that do not change during...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“Conference on Laser Polishing – LaP 2020”: The final touches for surfaces

23.07.2020 | Event News

Conference radar for cybersecurity

21.07.2020 | Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

 
Latest News

Anode material for safe batteries with a long cycle life

06.08.2020 | Power and Electrical Engineering

Turning carbon dioxide into liquid fuel

06.08.2020 | Life Sciences

Tellurium makes the difference

06.08.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>