Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

European membrane expertise to focus on new treatments for human diseases

18.03.2008
A new 15 million Euro project led by the University of Leeds aims to find novel treatments for many human diseases by bringing together the leading European experts in membrane proteins.

The project – the European Drug Initiative for Channels and Transporters (EDICT) – will target about 80 proteins, which play an important role in human diseases as varied as diabetes, heart disease, neuropsychiatric disorders like epilepsy and depression, osteoporosis, stomach ulcers and cataracts.

Membrane proteins are key to every process in the human body, channelling ions or transporting chemicals and so are ideal targets for new treatments. Infections by pathogenic bacteria, yeasts and parasites also involve their own membrane proteins, which can be specific targets for development of new drugs and antibiotics.

The research is mainly funded by the European Commission, involves twenty-seven partners from twelve countries – including two Nobel Laureates - and is set to last four years.

Coordinating the project is Peter Henderson, Professor of Biochemistry and Molecular Biology from Leeds’ Faculty of Biological Sciences.

“Membrane proteins are seen by many as the next potential source of drug development, and so the EC is keen to fund research in this area,” he said. “However, they are difficult to study and are poorly understood, though the recent sequencing of the human and other genomes show they make up about one third of all proteins in all organisms, including humans.”

“At the moment, few groups of membrane proteins are being seriously investigated by the pharmaceutical industry, so this project will help to fill that gap. By bringing together the best scientists in this challenging field from all over Europe, we hope to make a real advance towards new treatments for key diseases.”

Industry has also seen the benefit of bringing such expertise together under one umbrella and working with the academics will be pharmaceutical giant AstraZeneca and a smaller company, Xention, which specialises in the discovery and development of novel and selective ion channel drugs.

The researchers include biologists, structural biologists, chemists and experts in the three key technologies: x-ray crystallography, nuclear magnetic resonance, and electron microscopy.

The team aims to map out the structure of the proteins, so they can identify compounds that could be developed as a treatment for these diseases. Where they have already mapped some structures, the team will have a head start and hope to make real advances towards new treatments.

Other researchers joining the project from Leeds include Professors Steve Baldwin and Carola Hunte from the Faculty of Biological Sciences and Professor Peter Johnson and Dr Colin Fishwick from the School of Chemistry. All are members of Leeds’ Astbury Centre, the leading interdisciplinary research centre in the UK studying how life works at an atomic level.

The two Nobel Laureates involved in the research are Director of the Medical Research Council’s Dunn Human Nutrition Unit in Cambridge, Professor Sir John Walker, who also holds an honorary doctorate from the University of Leeds, and Director of the Max Planck Institute for Biophysics in Frankfurt, Germany, Professor Hartmut Michel.

Jo Kelly | alfa
Further information:
http://www.leeds.ac.uk/media

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>