Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Biocontrol presents data from First Superbug Clinical Trial

25.02.2008
The use of natural controls against serious bacterial infection and superbugs is being led by a UK company. Scientists at Biocontrol Ltd have today presented at the Bacteriophage 2008 meeting in Hertfordshire a first look at the results of their initial Phase II clinical trial.

This is the first fully-regulated clinical trial to test whether phage therapy really works and it shows positive results for Biocontrol’s innovative treatments, which attack and destroy previously untreatable bacterial infections.

Set up in 1997, Biocontrol has been developing the clinical use of bacteriophages – literally “eaters of bacteria” – that attack dangerous infection-causing bacteria. First discovered in the early 20th century, bacteriophages, or phages, are naturally occurring viruses that attack and destroy harmful bacteria. They are highly specialised, usually attacking only specific strains of a single species of bacteria.

Biocontrol’s clinical trial has been testing a treatment against the Pseudomonas aeruginosa bacteria – which is highly and increasingly resistant to traditional antibiotics and is a potential killer, especially when it infects the lungs – a future target for the Company.

Pseudomonas aeruginosa is also a major cause of ear infections, including the outer ear infection known as “swimmer’s ear.” Over a period of 17 months, from July 2006 to November 2007, a double-blind Phase II clinical trial took place at a specialist London hospital involving 24 patients with chronic ear infections that were not responding to antibiotic treatments. Results reported by both the patients who received Biocontrol’s phage treatment and the medical staff treating them, showed improvements. This amounted to a mean 50% reduction in symptoms, compared to a mean of only 20% in the control group who did not receive phages.

Among the most striking of the trial’s findings were the bacterial counts, analysed from samples taken from patients’ ears at periods of one, three and six weeks after the treatments were applied. In the test group of patients, the mean count of Pseudomonas aeruginosa bacteria present dropped by an average of around 80% by week three, and stayed there. By contrast, in the control group, the mean levels of bacteria showed a small increase over the same period.

Biocontrol’s founder and Chief Scientific Officer, Dr David Harper, commented: “This is the first fully-regulated double-blind clinical trial of the efficacy of a phage treatment, and is exactly what is needed to find out whether such a treatment really works. The fact that patients seem to have been getting better is the most exciting thing. Obviously a major part of the trial was monitoring to ensure that the treatments were safe – and there were no reportable safety events throughout, another very positive result.

“Originally designed for 40 patients, the trial was halted after 24, as patients seemed to be getting better. The Company, working with the clinicians in charge, has decided to move on with bringing such a potentially important treatment to the market as quickly as possible. We are also planning to offer phage treatment to the patients who did not receive it during the trial.”

Commenting on the successful outcome, the clinical director of the trials, Professor Tony Wright, Consultant ENT surgeon at the Royal National Throat, Nose and Ear Hospital in London, said: “All the patients had long histories of ear problems that had failed to respond to all sorts of treatments including topical and oral antibiotics, and sometimes even surgery. Some had had problems for more than 40 years.”

The next step for Biocontrol is to obtain permission for the pivotal Phase III clinical trial for the treatment that has now completed the Phase II trial.

Dr Harper said: “We want to get the Phase III trial for the ear treatment up and running as soon as possible. In addition, Pseudomonas aeruginosa bacteria are particularly dangerous when infecting the lungs of patients with cystic fibrosis. 80% of adult CF sufferers have chronic lung infections and it is the major cause of death in these patients. We are currently working on the development of an aerosol treatment that we hope will also produce a positive outcome in trials that we plan to start in late next year.

“We are also fundraising now to be able to take these trials forward, and are considering an IPO in 2009 to secure the levels of investment needed to take our products to market.”

Biocontrol is based in London, and as part of ongoing expansion, the Company has recently opened laboratories in Nottingham, close to the planned centre for next year’s trial. It has taken space in the BioCity complex – the leading centre for bioscience and healthcare sector companies in the East Midlands.

Welcoming Biocontrol, BioCity Nottingham’s Chief Executive Officer, Glenn Crocker, said: “We are delighted that Biocontrol has joined us at BioCity Nottingham. It is exactly the sort of fast growing company, developing truly innovative healthcare products that we were established to attract. Everyone is aware of the problems dealing with bacterial infections and Biocontrol’s products are increasingly being shown to be an effective solution.”

Regulatory note: The information contained in this release relates to the outcomes of an initial (Phase 1/2) clinical trial. The experimental treatment referred to will require successful completion of additional, large scale trials before being the subject of application for marketing approvals by appropriate regulatory bodies. It will not be available for the general treatment of patients until such a process is completed.

Margaret Henry | alfa
Further information:
http://www.biocontrol-ltd.com

More articles from Health and Medicine:

nachricht Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine

nachricht UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

Im Focus: The force of the vacuum

Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.

The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Small but ver­sat­ile; key play­ers in the mar­ine ni­tro­gen cycle can util­ize cy­anate and urea

10.12.2018 | Life Sciences

New method gives microscope a boost in resolution

10.12.2018 | Physics and Astronomy

Carnegie Mellon researchers probe hydrogen bonds using new technique

10.12.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>