Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New cancer vaccine platform a potential tool for efficacious targeted cancer therapy

08.10.2018

Researchers at the Faculty of Pharmacy have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses currently in clinical use. With the help of this new cancer vaccine platform, the activation of the human immune response against cancer cells becomes significantly more effective.

"What is actually the most remarkable insight concerning the PeptiENV cancer vaccine platform is that we are able to envelop oncolytic viruses with the patient's own cancer peptides, enabling tailored targeted treatment," says Erkko Ylösmäki, an Academy of Finland post-doctoral researcher working in the ImmunoViroTherapy Lab of the Faculty of Pharmacy, University of Helsinki.


This is a cancer vaccine platform, which consists of silver colored enveloped viruses, onto which a patient's cancer peptides has been tied to (in white, green and pink).

Credit: Vincenzo Cerullo

Oncolytic viruses are naturally occurring viruses that have been modified to restrict their division into cancer cells only. Virotherapy is usually administered as an injection to the tumour or the abdominal cavity, or intravenously.

A virus enveloped with peptides through the PeptiENV platform can effectively "train" the patient's own, locally active T cells to identify tumour cells. Thus, the amount of T cells able to identify tumour cells increases in the cancerous tissue, improving the efficacy of the cancer therapy.

The study demonstrated the functionality of the PeptiENV cancer vaccine platform in conjunction with oncolytic enveloped herpes simplex virus 1, already used in the treatment of metastatic melanoma. Oncolytic vaccinia viruses, among others currently under investigation in clinical trials, are also compatible with the cancer vaccine platform.

Additionally, the number of T cells in the cancerous tissue that are able to identify cancer cells strongly correlates with the therapeutic effect of new immune checkpoint inhibitors.

"We aim to expand the pool of patients that could potentially benefit from the unparalleled efficacy of immune checkpoint inhibitors," Ylösmäki explains.

Erkko Ylosmaki | EurekAlert!
Further information:
https://www.helsinki.fi/en/news/life-science-news/new-cancer-vaccine-platform-a-potential-tool-for-tailored-and-efficacious-targeted-cancer-therapy
http://dx.doi.org/10.1016/j.ymthe.2018.06.008

More articles from Health and Medicine:

nachricht Novel communication between intestinal microbes and developing immune cells in the thymus
24.01.2020 | Massachusetts General Hospital

nachricht Preventing metastasis by stopping cancer cells from making fat
23.01.2020 | Université catholique de Louvain

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Integrate Micro Chips for electronic Skin

Researchers from Dresden and Osaka present the first fully integrated flexible electronics made of magnetic sensors and organic circuits which opens the path towards the development of electronic skin.

Human skin is a fascinating and multifunctional organ with unique properties originating from its flexible and compliant nature. It allows for interfacing with...

Im Focus: Dresden researchers discover resistance mechanism in aggressive cancer

Protease blocks guardian function against uncontrolled cell division

Researchers of the Carl Gustav Carus University Hospital Dresden at the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international...

Im Focus: New roles found for Huntington's disease protein

Crucial role in synapse formation could be new avenue toward treatment

A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative...

Im Focus: A new look at 'strange metals'

For years, a new synthesis method has been developed at TU Wien (Vienna) to unlock the secrets of "strange metals". Now a breakthrough has been achieved. The results have been published in "Science".

Superconductors allow electrical current to flow without any resistance - but only below a certain critical temperature. Many materials have to be cooled down...

Im Focus: Programmable nests for cells

KIT researchers develop novel composites of DNA, silica particles, and carbon nanotubes -- Properties can be tailored to various applications

Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

„Advanced Battery Power“- Conference, Contributions are welcome!

07.01.2020 | Event News

 
Latest News

The synthesis of bio-based high-performance polyamide from biogenic residues: A real alternative to crude oil

27.01.2020 | Life Sciences

Superfast insights into cellular events

27.01.2020 | Life Sciences

The 'place' of emotions

27.01.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>