Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mild thyroid dysfunction in early pregnancy linked to serious complications

25.06.2012
Even moderate thyroid dysfunction during early pregnancy significantly increases the risk of serious complications, underscoring the need for universal screening in the first trimester, a new study finds. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

"These findings add to the now increasing evidence from previous studies that all pregnant women, irrespective of their risk for thyroid problems, probably should be screened for thyroid dysfunction within the first three months of getting pregnant," said study lead author Jubbin Jagan Jacob, M.D., associate professor at Christian Medical College and Hospital, Ludhiana in Punjab, India.

Thyroid hormone is produced by the thyroid gland, which is located in the neck, and helps regulate the process of turning food into energy. Excessively low hormone production, or hypothyroidism, may cause symptoms like fatigue, sensitivity to cold temperatures, constipation, and depression.

During pregnancy untreated, hypothyroidism is associated with an increased risk of miscarriage, stillbirth, low birth weight, and other serious complications. Although previous research has suggested that women with moderate thyroid dysfunction, or subclinical hypothyroidism, also are more likely to suffer complications, the level of risk was uncertain.

In this study, investigators found that even mild thyroid dysfunction that did not meet the criteria for hypothyroidism greatly increased the risk of serious problems. Compared to pregnant women with normal thyroid function, the risk was:

- doubled for miscarriage (¡Ü20 weeks of pregnancy), premature labor, and low birth weight

- seven times greater for still birth

Screening for hypothyroidism involves taking a thorough history of symptoms, as well as a simple blood test to measure levels of another hormone, called thyroid-stimulating-hormone, or TSH, that promotes thyroid-hormone production. At this time, only pregnant women with clinical symptoms of hypothyroidism are routinely tested. Once diagnosed, the condition can be effectively controlled with medication that replaces natural thyroid hormone with a synthetic version.

Investigators recruited 1,000 pregnant women in their first trimester of pregnancy for the study, as part of a larger project of routine thyroid screening during early pregnancy. They then measured the level of thyroid functioning using the TSA test.

Normal thyroid function was identified in 533 patients, and 263 had mild dysfunction. The remaining patients were diagnosed with hypothyroidism and withdrawn from the study for treatment. Follow-up continued until the completion of pregnancy.

Jacob and his team then compared rates of miscarriage, stillbirth, premature labor, and low birth weight. They also analyzed several other complications, as well, but these did not differ significantly between women with normal versus moderately low thyroid functioning.

"Our conclusions are that all pregnant women need to be screened for thyroid dysfunction at their first visit," Jacob said. "This should form the basis for the national societies to make a change in their guidelines." Christian Medical College and Hospital funded the study.

Aaron Lohr | EurekAlert!
Further information:
http://www.endo-society.org

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Solving the efficiency of Gram-negative bacteria

22.03.2019 | Life Sciences

Bacteria bide their time when antibiotics attack

22.03.2019 | Life Sciences

Open source software helps researchers extract key insights from huge sensor datasets

22.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>