In his doctoral dissertation at SLU, the Swedish University of Agricultural Sciences, veterinarian Patricio Rivera identifies various risk factors for developing mammary tumors in dogs. Genetic causes, among others, contribute to the outbreak of the disease in certain breeds, including English Springer spaniel, Doberman, boxer, and German shepherd.
Even though this research focused on mammary tumors in dogs, there has been a human connection in many of his studies. Mammary tumors in female dogs are three times more common than breast cancer in women.
Patricio Rivera found that spaying reduces the risk of mammary tumors and that the age of the dog when it is diagnosed and the type of mammary tumor both affect the survival period of the animal.
By studying the ten genes that cause breast cancer in women, he found that the two most common genes in humans, BRCA1 and BRCA2, also contribute to the risk of mammary tumors in female English Springer spaniels.
In dogs he also found a variant of a gene, a so-called haplotype, tied to the immune defense that had a protective effect against mammary tumors. Female English Springer spaniels that carry this gene have a lower risk of developing mammary tumors than others of the same breed.
“It’s my hope that this research will ultimately be of significance both for women and female dogs when it comes to diagnosis and treatment,” says Patricio Rivera.
The earlier tumors are discovered – the better the prognosis for survival. Just as women should examine their breasts, dog owners are recommended to regularly check their female dogs for lumps.
Mammary tumors are the most common tumor disease in female dogs, appearing most frequently in middle-aged and older animals. More than 50 percent of the tumors are benign and do not spread to other parts of the body.
The malignant tumors, on the other hand, have a potential to spread and establish daughter tumors in other organs and tissues. The female dog often develops tumors in multiple parts of the mammary glands at the same time, and these tumors can be of various kinds.
The most reliable method of diagnosis is microscopic examination of tissue (biopsy) from the tumor. As a rule, a malignant mammary tumor will be removed by surgery, but the prognosis after the operation is very individual and depends on the nature of the tumor, among other factors.
Spaying at an early age, preferably before the female dog reaches sexual maturity, is the most radical and reliable method to avoid mammary tumors in dogs. The tumor’s development is dependent on sex hormones. On the other hand, if the dog is given contraceptive injections or some other hormonal treatment during her life, there is an increased risk of developing mammary tumors.
In his research, Patricio Rivera collected blood samples from 600 female dogs between the ages of two and fourteen years of the English Springer spaniel breed and a number of dogs of other breeds. By comparing the genes of sick and healthy dogs, he found gene variants that impact the risk of developing mammary tumors in the breed under study.
These samples now constitute a unique and important biological material that can serve as a foundation for future research in the field.
“At present there are no genetic tests that can tell us which dogs carry genes that predispose them for mammary tumors, but I hope to be able to continue to do research on this,” says Patricio Rivera.
For more information: Patricio Rivera phone: +46 (0)18-67 29 57; mobile: +46 (0)70-37 94 800 firstname.lastname@example.org
Pressofficer Cain Wrange;Carin.Wrange@adm.slu.se; 070-247 84 22
Carin Wrange | idw
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences