Massachusetts General Hospital (MGH) researchers have developed a new type of miniature endoscope that produces three-dimensional, high-definition images, which may greatly expand the application of minimally invasive diagnostic and therapeutic procedures. In the October 19 issue of Nature, the team from the Wellman Center for Photomedicine at MGH describes their prototype device and a demonstration of its use in a mouse model.
The spectral encoded miniature endoscope uses micro optics and a single optical fiber to project various colors of light onto different portions of the subject. The light reflected back into the endoscope is measured and analyzed to produce a three-dimensional image. This illustration shows a time exposure of white light transmitted through the miniature endoscope, superimposed on a three-dimensional rendering of mouse metastatic ovarian tumor nodules obtained with this new technique. Credit: Wellman Center for Photomedicine, Massachusetts General Hospital
"This new ultraminiature endoscope is the first to allow three-dimensional imaging of areas inside the body," says Guillermo Tearney, MD, PhD, of the MGH Wellman Center, the report's senior author. "Its ability to go places that other imaging tools cannot reach opens new possibilities for medical diagnosis and eventually treatment."
Standard miniature endoscopic devices – which give physicians access to hard-to-reach internal organs and structures – utilize bundles of optical fibers to supply light to and transmit images from the areas of interest. Larger endoscopes that use image sensors to produce high-quality, two-dimensional images can be a centimeter or more in diameter. Existing miniature endoscopes using smaller fiber bundles may be more flexible but have difficulty producing high-quality images.
The new device developed at MGH-Wellman uses a technology called spectrally encoded endoscopy (SEE). Multicolored light from a single optical fiber – introduced through a probe about the size of a human hair – is broken into its component colors and projected onto tissue, with each color illuminating a different part of the tissue surface. The light reflected back is recorded, and the intensity of the various colors decoded by a spectrometer, which analyzes the wavelengths of light. Another device called an interferometer, which calculates structural information based on the interaction between two waves of light, provides the data required to create three-dimensional images.
To demonstrate the device's application in a live animal, the researchers used the system to image metastatic ovarian tumors on the abdominal wall of a mouse. The SEE probe was passed into the abdominal cavity through a fine-gauge needle. The resulting three-dimensional image showed several raised areas of tumor nodules, the presence of which was confirmed by histologic analysis of the tissue.
"The most important feature of this new endoscope is the ability to obtain three-dimensional images, something we don't believe is offered by any commercially available miniature endoscope system," says Dvir Yelin, PhD, first author of the Nature paper. "While the image resolution we achieved in this demonstration is similar to existing small-diameter endoscopes, with further optimization of the optics it is possible to obtain images with 10 times the number of pixels provided by other miniature endoscopes."
"This new technology will offer physicians and surgeons the capability to bring many more procedures into outpatient settings, reduce anesthesia requirements and minimize tissue damage," Tearney adds. "The device's size and flexibility should allow safer navigation through such delicate structures as the salivary ducts, the fallopian tubes and the pancreatic duct. Fetal and pediatric procedures may also benefit from this tool. Eventually, SEE could give rise to new procedures that permit diagnosis and microsurgery in previously inaccessible areas of the body."
Sue McGreevey | EurekAlert!
Can radar replace stethoscopes?
14.08.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Novel PET imaging method could track and guide therapy for type 1 diabetes
03.08.2018 | Society of Nuclear Medicine and Molecular Imaging
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences