Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Insights into Micromillimeters

03.07.2008
New high-tech imaging center “TIGA” at the University of Heidelberg / Robot “NanoZoomer” shows high-resolution images of cells and tissue

“TIGA,” the new high-tech imaging center at the University of Heidelberg founded in cooperation with the Japanese company Hamamatsu, provides deep insights: a high-tech robot makes it possible for the first time to automatically reproduce and evaluate tissue slices only micromillimeters thick – an important aid for researchers in understanding cancer or in following in detail the effect of treatment on cells and tissue.

The Hamamatsu Tissue Imaging and Analysis (TIGA) Center is a cooperative effort between the Institutes of Pathology and of Medical Biometry and Informatics at the University of Heidelberg and the Japanese company Hamamatsu Photonics. In addition, it belongs to BIOQUANT, the research center for quantitative biology at the University of Heidelberg. At its core is the imaging robot “NanoZoomer” from Hamamatsu Photonics: the robot scans the tissue slices and displays them on the monitor for researchers at ultra high resolution and in various planes.

“Technically, this has brought the fully automatic evaluation of tissue changes and approaches for new therapy within our grasp,” states Professor Dr. Peter Schirmacher, Director of the Institute for Pathology at Heidelberg University Hospital. This would represent a new milestone in pathology.

Detailed images help understand diseases

Which proteins are formed to a greater degree in cancer cells? How is tumor tissue changed during radiation treatment? Thanks to the NanoZoomer’s high-resolution images and special evaluation programs, researchers in the future will be able to evaluate tissue and cell samples more quickly and accurately and gain important new insights for therapy tailored to the individual patient, for example for breast cancer.

In the future, the robot will be able to determine changes in cells and tissue fully automatically. “The NanoZoomer represents a quantum leap in tissue research,” says Dr. Niels Grabe of the Institute for Medical Biometry and Informatics and research director at the TIGA Center.

Virtual Tissue is modeled from data

The medical IT specialists use the NanoZoomer to evaluate huge quantities of data from tissues for their research. For example, Dr. Niels Grabe and his team used data to model virtual skin tissue. “On a computer model of human skin tissue we can test whether certain substances are toxic, for example,“ explains Dr. Grabe. “In the future, this could make it easier to develop potential new drugs.”

Hamamatsu recognized the many possible applications early on, so that new technological markets have now been opened up for them. “We are happy to have found two partners in the Heidelberg Institute of Pathology and the Institute of Medical Biometry and Informatics with whom we can develop concrete clinical uses and new applications for research,” said Hideo Hiruma, Managing Director of Hamamatsu Photonics, Japan.

Contact:

Dr. Niels Grabe
Research Director at the TIGA center
Tel.: +49 6221 / 56 5143
E-Mail: niels.grabe@med.uni-heidelberg.de

Professor Dr. Peter Schirmacher
Director of the Institute for Pathology
at Heidelberg University Hospital
Phone: +49 6221 / 56 2601
E-Mail: peter.schirmacher@med.uni-heidelberg.de

Hamamatsu Photonics, Germany and Japan:
Hamamatsu Germany is the German subsidiary of Hamamatsu Photonics K.K. (Japan), a leading manufacturer of devices for the generation and measurement of infrared, visible, and ultraviolet light. These devices include photodiodes, photomultiplier tubes, scientific light sources, infrared detectors, photoconductive cells, image sensors and integrated measurement systems for science and industry. The parent company is dedicated to the advancement of photonics through extensive research. This corporate philosophy results in state-of-the-art products which are used throughout the world in scientific, industrial, and commercial applications.

Institute of Pathology, University Heidelberg:

The Institute of Pathology at the University Heidelberg contributes to patient care, teaching, advanced training, quality management and research. Key task is the diagnostic evaluation of tissues (histology) and cell preparations (cytology). The Institute analyses more than 60.000 samples from operative and conservative medicine which are an elementary component of clinical diagnostics and therapy planning. The Institute is consulting in many areas, for example tumor diagnostics.

Institute of Medical Biometry and Informatics, University Heidelberg:

The Institute of Medical Biometry and Informatics at the University Heidelberg contributes to teaching, advanced training and clinical research. Biometry is concerned with the methodology and realization of therapeutic-, diagnostic- and meta studies. Research subjects of medical informatics includes bioinformatics/systems biology, knowledge based diagnosis and therapy, the management of health data, as well as medical image processing and pattern recognition. In collaboration with the University Heilbronn, the institute is conducting Germany’s eldest curriculum on medical informatics.

Requests by journalists:
Dr. Annette Tuffs
Head of Public Relations and Press Department
University Hospital of Heidelberg and
Medical Faculty of Heidelberg
Im Neuenheimer Feld 672
D-69120 Heidelberg
Germany
phone: +49 6221 / 56 45 36
fax: +49 6221 / 56 45 44
e-mail: annette.tuffs(at)med.uni-heidelberg.de

Dr. Annette Tuffs | EurekAlert!
Further information:
http://www.med.uni-heidelberg.de

More articles from Medical Engineering:

nachricht Therapies without drugs
25.02.2020 | Fraunhofer-Institut für Zuverlässigkeit und Mikrointegration IZM

nachricht Active droplets
21.02.2020 | Technical University of Munich (TUM)

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: High-pressure scientists in Bayreuth discover promising material for information technology

Researchers at the University of Bayreuth have discovered an unusual material: When cooled down to two degrees Celsius, its crystal structure and electronic properties change abruptly and significantly. In this new state, the distances between iron atoms can be tailored with the help of light beams. This opens up intriguing possibilities for application in the field of information technology. The scientists have presented their discovery in the journal "Angewandte Chemie - International Edition". The new findings are the result of close cooperation with partnering facilities in Augsburg, Dresden, Hamburg, and Moscow.

The material is an unusual form of iron oxide with the formula Fe₅O₆. The researchers produced it at a pressure of 15 gigapascals in a high-pressure laboratory...

Im Focus: From China to the South Pole: Joining forces to solve the neutrino mass puzzle

Study by Mainz physicists indicates that the next generation of neutrino experiments may well find the answer to one of the most pressing issues in neutrino physics

Among the most exciting challenges in modern physics is the identification of the neutrino mass ordering. Physicists from the Cluster of Excellence PRISMA+ at...

Im Focus: Therapies without drugs

Fraunhofer researchers are investigating the potential of microimplants to stimulate nerve cells and treat chronic conditions like asthma, diabetes, or Parkinson’s disease. Find out what makes this form of treatment so appealing and which challenges the researchers still have to master.

A study by the Robert Koch Institute has found that one in four women will suffer from weak bladders at some point in their lives. Treatments of this condition...

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

Physicists from Hannover Predict Novel Light Molecules

26.02.2020 | Physics and Astronomy

Turbomachine expander offers efficient, safe strategy for heating, cooling

25.02.2020 | Power and Electrical Engineering

The seismicity of Mars

25.02.2020 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>