Developed in collaboration with industrial scientists at Perdix and Malvern Instruments, the new process analytical technology (PAT) tool characterises particle shapes using a probe which collects images of the crystallization process. The tool will enable pharmaceutical companies to monitor and optimise these processes.
“Essentially we’re filming inside the reactor so you can see exactly what’s happening as crystals are forming – and we’ve shown that we can do this on a large scale,” says Professor Kevin Roberts of the University's Institutes of Process R&D (iPRD) and Particle Science and Engineering (IPSE). “I believe we can help the manufacturing process become faster and more efficient, which will cut waste and save money - and shorten the time it takes drugs to get to market.”
Crystallisation of drug compounds from solution is a fundamental part of the lengthy pharmaceutical processing chain. The size and shape of drug compound crystals has a significant effect on product purity and quality. It also impacts on other parts of the process, where crystals are sifted, milled and blended with other chemicals before being made into tablets or suspensions.
The Leeds technology uses a probe called the In-Situ Particle Viewer (ISPV) designed and built by Perdix, in combination with Morphologi®, a commercial image analysis software developed by Malvern Instruments.
Until now there has been little research into how crystal formation can be monitored and controlled. Optimising crystal formation at the beginning of the manufacturing process could significantly affect the efficiency of the production chain, says Professor Roberts.
He believes that technologies such as those being developed at Leeds have the potential to revolutionise the pharmaceutical manufacturing sector. “The development of new technologies and processes to ensure that drug manufacture is lean and efficient is crucial. Getting it right first time requires an in depth understanding of each of the component parts of the manufacturing chain,” he says.
“Essentially we’re working towards developing high quality ‘Six Sigma’ manufacturing processes for the pharma sector - very much mirroring the approaches already adopted by high-tech sectors such as microelectronics.”
Jo Kelly | alfa
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
Pollen taxi for bacteria
18.07.2018 | Technische Universität München
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
18.07.2018 | Materials Sciences
18.07.2018 | Life Sciences
18.07.2018 | Health and Medicine