Microorganisms are considered as dirty organism that threaten our health, decay food and cause inconvenience in our daily life. However, they are playing a critical role in making nutrients by metabolizing food, allowing all living creatures to live on. Especially, there are 2,000 kinds of microorganisms and several hundred trillions in figures living in our body. Most of these microorganisms live in digestive tracts but their effect is shown in our entire body. Recently, the research team of POSTECH (Pohang University of Science and Technology, President Moohwan Kim) discovered how microbiota transmit signals to entire body and control hematopoiesis in the bone marrow.
Professor Seung-Woo Lee, Research Professor Yunji Park, Master/PhD integrated program students, Seungwon Lee and Hyekang Kim of Division of Integrative Biosciences and Biotechnology from POSTECH described the mechanism how microbiota signals are sent to different organs.
CX3CR1+ mononuclear cells (colored in green) are contacting hematopoietic progenitors (colored in purple) in the bone marrow. When CX3CR1+ mononuclear cells recognize the microbiota signals, they produce inflammatory cytokines which expedite the hematopoiesis.
Credit: POHANG UNIVERSITY OF SCIENCE & TECHNOLOGY (POSTECH)
Also, they utilized imaging research to prove that CX3CR+ mononuclear cells contact hematopoietic progenitors for the first time in history. Their research is introduced as a featured content in the journal of the American Society of Hematology, Blood.
Recent researches on microorganism concluded that microbiota control biological phenomenon not only in digestive tracts but also in lung, liver, brain, bone marrow and other organs. But, none of them were able to define a mechanism for relaying microbiota signals to entire body or for producing immune cells by receiving microbiota signals.
Professor Lee and his research team focused on the fact that the microbiota regulate the immune system of our body by controlling hematopoiesis in the bone marrow to produce white blood cells. In this process, the team discovered that the microbiota signal including bacterial DNA is transferred to the bone marrow through bloodstream and CX3CR1+ mononuclear cells in the bone marrow recognize this signal.
They explained that when CX3CR1+ mononuclear cells recognize microbiota signals, they release signal substances called cytokines which control and stimulate body's defense system through the signal transduction. They also explained that cytokines control the number of hematopoietic progenitors or stimulate differentiation into myeloid lineages to make blood cells.
Furthermore, they verified that CX3CR1+ mononuclear cells contact hematopoietic progenitors at the perivascular region and they play as a signal receiving microbiota signals.
They discovered the hematopoiesis control mechanism which is controlled by cytokines produced when CX3CR1+ mononuclear cells recognize microbiota signals transferred to the bone marrow.
Professor Seung-Woo Lee commented, "For the first time, our research describes the mechanism that had not been explained how microbiota regulate not only digestive tracts but also entire body response. It might be possible to apply this study to control immune response in other parts of a body or to treat cancer and inflammatory disease via microbiota signal pathway.
This study was financially supported by National Research Foundation of Korea, Regional Leading Research Center, and Korea Ministry of Science and ICT under BK21 Plus project.
Jinyoung Huh | EurekAlert!
Researchers discover vaccine to strengthen the immune system of plants
24.01.2020 | Westfälische Wilhelms-Universität Münster
Brain-cell helpers powered by norepinephrine during fear-memory formation
24.01.2020 | RIKEN
Researchers from Dresden and Osaka present the first fully integrated flexible electronics made of magnetic sensors and organic circuits which opens the path towards the development of electronic skin.
Human skin is a fascinating and multifunctional organ with unique properties originating from its flexible and compliant nature. It allows for interfacing with...
Researchers of the Carl Gustav Carus University Hospital Dresden at the National Center for Tumor Diseases Dresden (NCT/UCC), together with an international...
A Duke University research team has identified a new function of a gene called huntingtin, a mutation of which underlies the progressive neurodegenerative...
For years, a new synthesis method has been developed at TU Wien (Vienna) to unlock the secrets of "strange metals". Now a breakthrough has been achieved. The results have been published in "Science".
Superconductors allow electrical current to flow without any resistance - but only below a certain critical temperature. Many materials have to be cooled down...
KIT researchers develop novel composites of DNA, silica particles, and carbon nanotubes -- Properties can be tailored to various applications
Using DNA, smallest silica particles, and carbon nanotubes, researchers of Karlsruhe Institute of Technology (KIT) developed novel programmable materials....
16.01.2020 | Event News
15.01.2020 | Event News
07.01.2020 | Event News
24.01.2020 | Life Sciences
24.01.2020 | Life Sciences
24.01.2020 | Life Sciences