Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Superresolution live-cell imaging provides unexpected insights into the dynamic structure of mitochondria

18.02.2020

As power plants and energy stores, mitochondria are essential components of almost all cells in plants, fungi and animals. Until now, it has been assumed that these functions underlie a static structure of mitochondrial membranes. Researchers at the Heinrich Heine University Düsseldorf (HHU) and the University of California Los Angeles (UCLA) and have now discovered that the inner membranes of mitochondria are by no means static, but rather constantly changing their structure every few seconds in living cells. This dynamic adaptation process further increases the performance of our cellular power plants.

"In our opinion, this finding fundamentally changes the way our cellular power plants work and will probably change the textbooks," says Prof. Dr. Andreas Reichert, Institute of Biochemistry and Molecular Biology I at the HHU. The results are described in a publication in EMBO Reports.


Animated video: Cristae membranes dynamically adapt their structures in the living cell

Quelle: Prof. Dr. Andreas Reichert, HHU Düsseldorf

Mitochondria are extremely important components in cells performing vital functions including the regulated conversion of energy from food into chemical energy in the form of ATP. ATP is the energy currency of cells and an adult human being produces (and consumes) approximately 75 kilograms of ATP per day.

One molecule of ATP is produced about 20,000 times a day and then consumed again for energy utilization. This immense synthesis capacity takes place in the inner membrane of the mitochondria, which has numerous folds called cristae.

It was previously assumed that a specific static structure of the cristae ensured the synthesis of ATP. Whether and to what extent cristae membranes are able to dynamically adapt or alter their structure in living cells and which proteins are required to do so, was unknown.

The research team of Prof. Dr. Andreas Reichert with Dr. Arun Kondadi and Dr. Ruchika Anand from the Institute of Biochemistry and Molecular Biology I of the HHU in collaboration with the research team of Prof. Dr. Orian Shirihai and Prof. Dr. Marc Liesa from UCLA (USA) succeeded for the first time in showing that cristae membranes in living cells continuously change their structure dynamically within seconds within mitochondria.

This showed that the cristae membrane dynamics requires a recently identified protein complex, the MICOS complex. Malfunctions of the MICOS complex can lead to various serious diseases, such as Parkinson's disease and a form of mitochondrial encephalopathy with liver damage.

After the identification of the first protein component of this complex (Fcj1/Mic60) about ten years ago by Prof. Andreas Reichert and his research group, this is another important step to elucidate the function of the MICOS complex.

"Our now published observations lead to the model that cristae, after membrane fission, can exist for a short time as isolated vesicles within mitochondria and then re-fuse with the inner membrane. This enables an optimal and extremely rapid adaptation to the energetic requirements in a cell," said Prof. Andreas Reichert.

Wissenschaftliche Ansprechpartner:

Prof. Dr. Andreas Reichert
Institute of Biochemistry and Molecular Biology I
University Hospital Düsseldorf
Medical Faculty, Heinrich-Heine University Duesseldorf, Germany
Tel.: +4921181-12707, -12717
reichert@hhu.de

Originalpublikation:

EMBO Reports, Kondadi et al.: https://www.embopress.org/doi/10.15252/embr.201949776

Susanne Dopheide | idw - Informationsdienst Wissenschaft
Further information:
http://www.hhu.de/

More articles from Life Sciences:

nachricht TU Dresden chemists develop noble metal aerogels for electrochemical hydrogen production and other applications
06.04.2020 | Technische Universität Dresden

nachricht First SARS-CoV-2 genomes in Austria openly available
03.04.2020 | CeMM Forschungszentrum für Molekulare Medizin der Österreichischen Akademie der Wissenschaften

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: When ions rattle their cage

Electrolytes play a key role in many areas: They are crucial for the storage of energy in our body as well as in batteries. In order to release energy, ions - charged atoms - must move in a liquid such as water. Until now the precise mechanism by which they move through the atoms and molecules of the electrolyte has, however, remained largely unknown. Scientists at the Max Planck Institute for Polymer Research have now shown that the electrical resistance of an electrolyte, which is determined by the motion of ions, can be traced back to microscopic vibrations of these dissolved ions.

In chemistry, common table salt is also known as sodium chloride. If this salt is dissolved in water, sodium and chloride atoms dissolve as positively or...

Im Focus: Harnessing the rain for hydrovoltaics

Drops of water falling on or sliding over surfaces may leave behind traces of electrical charge, causing the drops to charge themselves. Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz have now begun a detailed investigation into this phenomenon that accompanies us in every-day life. They developed a method to quantify the charge generation and additionally created a theoretical model to aid understanding. According to the scientists, the observed effect could be a source of generated power and an important building block for understanding frictional electricity.

Water drops sliding over non-conducting surfaces can be found everywhere in our lives: From the dripping of a coffee machine, to a rinse in the shower, to an...

Im Focus: A sensational discovery: Traces of rainforests in West Antarctica

90 million-year-old forest soil provides unexpected evidence for exceptionally warm climate near the South Pole in the Cretaceous

An international team of researchers led by geoscientists from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) have now...

Im Focus: Blocking the Iron Transport Could Stop Tuberculosis

The bacteria that cause tuberculosis need iron to survive. Researchers at the University of Zurich have now solved the first detailed structure of the transport protein responsible for the iron supply. When the iron transport into the bacteria is inhibited, the pathogen can no longer grow. This opens novel ways to develop targeted tuberculosis drugs.

One of the most devastating pathogens that lives inside human cells is Mycobacterium tuberculosis, the bacillus that causes tuberculosis. According to the...

Im Focus: Physicist from Hannover Develops New Photon Source for Tap-proof Communication

An international team with the participation of Prof. Dr. Michael Kues from the Cluster of Excellence PhoenixD at Leibniz University Hannover has developed a new method for generating quantum-entangled photons in a spectral range of light that was previously inaccessible. The discovery can make the encryption of satellite-based communications much more secure in the future.

A 15-member research team from the UK, Germany and Japan has developed a new method for generating and detecting quantum-entangled photons at a wavelength of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

13th AKL – International Laser Technology Congress: May 4–6, 2022 in Aachen – Laser Technology Live already this year!

02.04.2020 | Event News

“4th Hybrid Materials and Structures 2020” takes place over the internet

26.03.2020 | Event News

 
Latest News

TU Dresden chemists develop noble metal aerogels for electrochemical hydrogen production and other applications

06.04.2020 | Life Sciences

Lade-PV Project Begins: Vehicle-integrated PV for Electrical Commercial Vehicles

06.04.2020 | Power and Electrical Engineering

Lack of Knowledge and Uncertainty about Algorithms in Online Services

06.04.2020 | Social Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>