Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists find differences in long-lived rodent’s protein handlers

14.05.2012
Animal’s good health likely tied to effective removal of damaged proteins

The naked mole-rat, a curiously strange, hairless rodent, lives many years longer than any other mouse or rat. Scientists at The University of Texas Health Science Center San Antonio’s Barshop Institute of Longevity and Aging Studies continue to explore this mystery.

On May 2 a Barshop Institute team reported that the naked mole-rat’s cellular machines for protein disposal — called proteasome assemblies — differ in composition from those of other short-lived rodents. The study is in the journal PLoS ONE.

This is the first report of the molecular mechanisms that underlie the naked mole-rat’s superior ability to maintain protein integrity. “More effective removal of damaged proteins within the cell would enable the animal to be able to maintain good function and is likely to contribute to its excellent maintenance of good health well into its third decade of life,” said Rochelle Buffenstein, Ph.D., of the Barshop Institute. Dr. Buffenstein is a professor of physiology and cellular and structural biology in the School of Medicine at the UT Health Science Center.

Protein integrity

Dr. Buffenstein and her research team in 2009 reported that the naked mole-rat maintains exceptional protein integrity throughout its long and healthy life. In the new study, the team found a greater number of proteasomes and higher protein-disposal activity in naked mole-rat liver cells.

The Barshop Institute scientists, including lead author Karl Rodriguez, Ph.D., postdoctoral fellow, and Yael Edrey, graduate student, also found large numbers of immunoproteasomes in the liver cells — a bit of a surprise because these protein disposers, which remove antigens after presentation in the immune system, are more commonly found in the spleen and thymus.

“Given the high levels of oxidative damage routinely seen in liver tissue of naked mole-rats, it is likely that, in the liver, these immunoproteasomes may play a critical role in the processing of oxidatively damaged proteins,” Dr. Buffenstein said.

Oxidative stress

Oxygen is a reactive molecule, rusting unsealed metals and darkening fruit. In the body over time, it is thought to cause an accumulation of damage leading to functional decline, diseases and aging. This is called the oxidative stress theory of aging.

Naked mole-rats, which live underground in the wild, exhibit high levels of oxidative stress even at a young age, yet do not show many signs of age-related decline until very late in life.

“The composition of proteasomes and the presence of immunoproteasomes in the liver are key pieces of the jigsaw puzzle evaluating how naked mole-rats preserve health span well into their third decade of life,” Dr. Buffenstein said.

Co-authors also included Barshop Institute members Maria Gaczynska, Ph.D., associate professor of molecular medicine in the School of Medicine, and Pawel Osmulski, Ph.D., assistant professor of molecular medicine.

The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 3 percent of all institutions worldwide receiving federal funding. Research and other sponsored program activity totaled $231 million in fiscal year 2011. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced approximately 28,000 graduates. The $736 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways “We make lives better®,” visit www.uthscsa.edu.

Will Sansom | EurekAlert!
Further information:
http://www.uthscsa.edu

More articles from Life Sciences:

nachricht Surprisingly many peculiar long introns found in brain genes
10.07.2020 | Moscow Institute of Physics and Technology

nachricht Did nerve cells evolve to talk to microbes?
10.07.2020 | Christian-Albrechts-Universität zu Kiel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The spin state story: Observation of the quantum spin liquid state in novel material

New insight into the spin behavior in an exotic state of matter puts us closer to next-generation spintronic devices

Aside from the deep understanding of the natural world that quantum physics theory offers, scientists worldwide are working tirelessly to bring forth a...

Im Focus: Excitation of robust materials

Kiel physics team observed extremely fast electronic changes in real time in a special material class

In physics, they are currently the subject of intensive research; in electronics, they could enable completely new functions. So-called topological materials...

Im Focus: Electrons in the fast lane

Solar cells based on perovskite compounds could soon make electricity generation from sunlight even more efficient and cheaper. The laboratory efficiency of these perovskite solar cells already exceeds that of the well-known silicon solar cells. An international team led by Stefan Weber from the Max Planck Institute for Polymer Research (MPI-P) in Mainz has found microscopic structures in perovskite crystals that can guide the charge transport in the solar cell. Clever alignment of these "electron highways" could make perovskite solar cells even more powerful.

Solar cells convert sunlight into electricity. During this process, the electrons of the material inside the cell absorb the energy of the light....

Im Focus: The lightest electromagnetic shielding material in the world

Empa researchers have succeeded in applying aerogels to microelectronics: Aerogels based on cellulose nanofibers can effectively shield electromagnetic radiation over a wide frequency range – and they are unrivalled in terms of weight.

Electric motors and electronic devices generate electromagnetic fields that sometimes have to be shielded in order not to affect neighboring electronic...

Im Focus: Gentle wall contact – the right scenario for a fusion power plant

Quasi-continuous power exhaust developed as a wall-friendly method on ASDEX Upgrade

A promising operating mode for the plasma of a future power plant has been developed at the ASDEX Upgrade fusion device at Max Planck Institute for Plasma...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Contact Tracing Apps against COVID-19: German National Academy Leopoldina hosts international virtual panel discussion

07.07.2020 | Event News

International conference QuApps shows status quo of quantum technology

02.07.2020 | Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

 
Latest News

Looking at linkers helps to join the dots

10.07.2020 | Materials Sciences

Surprisingly many peculiar long introns found in brain genes

10.07.2020 | Life Sciences

Goodbye Absorbers: High-Precision Laser Welding of Plastics

10.07.2020 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>