Kawasaki disease, an acute, self-limited vasculitis, is the leading cause of acquired heart disease in children in developed countries, but its aetiologic and pathogenic mechanisms remain unclear.
A team of researchers led by David Relman, Stanford University, US, and Jane Burns, University of California at San Diego, US, characterized the gene expression patterns that occur in the blood cells of patients with this disease. They examined genome-wide transcript expression patterns in the blood of 77 children with Kawasaki disease.
The acute phase of the illness was accompanied by an increase in gene transcripts associated with innate immune mechanisms and proinflammatory responses, and a decrease in transcripts associated with natural killer cells and CD8+ lymphocytes, which help clear infected or abnormal cells from the body.
They showed that the transcript patterns during the acute phase of the disease varied dramatically with day of illness, and that differences in expression patterns between patients were associated with clinical parameters that physicians have used to manage and make predictions about the course of the disease. Patients who showed higher expression levels of specific transcripts (e.g., carcinoembryonic antigen-related cell adhesion molecule 1; CEACAM1) were less likely to respond to intravenous immunoglobulin, a highly effective but poorly understood treatment for preventing coronary artery aneurysms and reducing fever in Kawasaki disease.
This work contributes to our understanding of how the disease develops, how the treatment works, and how doctors might identify patients who are candidates for other therapies.
Protein interaction helps Yersinia cause disease
21.08.2018 | Schwedischer Forschungsrat - The Swedish Research Council
Nanobot pumps destroy nerve agents
21.08.2018 | American Chemical Society
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
The low current is considered one of the biggest hurdles in the development of solid-state batteries. It is the reason why the batteries take a relatively long...
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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21.08.2018 | Medical Engineering