Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New discoveries about nitric oxide can provide drugs for schizophrenia

21.11.2007
Problems with memory and social function in patients with schizophrenia may result from an imbalance in the brain's nitric oxide system. A dissertation from the Sahlgrenska Academy shows that rats with characteristics of schizophrenia regain normal brain function if they receive drugs that reduce the production of nitric oxide in the brain.

Schizophrenia is a serious and common disease that can cause hallucinations, delusions and apathy. Problems with memory, social cognition and other intellectual abilities are also common.

"Schizophrenic patients can be treated with anti-psychotic drugs, but the treatment does not help cognitive disturbances or impaired social function to any appreciable degree. We believe that this is due to an imbalance in the brain's nitric oxide system, and if this is the case, we may be able to develop a completely new type of treatment," says pharmacologist Caroline Wass.

In these studies, rate and mice were given a drug called phencyclidine. This substance causes a schizophrenia-like state in humans.

... more about:
»Oxide »Wass »function »nitric »schizophrenia

"Rats and mice don't become schizophrenic, but the drug has a similar effect on thought processes in rodents to the effect it has in humans," says Caroline Wass.

The animals' learning capacity, memory and social interaction were measured using several different behaviour models. When the animals were treated with a substance that blocks brain nitric oxide production, they became resistant to the schizophrenia-like effects of phencyclidine.

The research team will shortly initiate a patient study in order to find out whether blocking brain nitric oxide production can alleviate cognitive disturbances in patients with schizophrenia.

"In the future it is possible that drugs that affect the regulation of nitric oxide in the brain can be used to supplement currently existing anti-psychotic agents. The hope is that nitric oxide inhibiting drugs will alleviate the cognitive disturbances that also lie behind the impairments of social function, significantly improving the chances of a good life for schizophrenic patients," says Caroline Wass.

SCHIZOPHRENIA FACTS
Schizophrenia is a psychiatric illness that affects 1% of the population. There is no cure, but the psychotic symptoms can be treated with psychotropic drugs. The illness often first appears in the twenties. It is usually chronic, and most sufferers never return to work or to full-time education.
Dissertation for research doctorate in medicine from the Sahlgrenska Academy, Institute of Neuroscience and Physiology
Title of dissertation: Cognition and social behaviour in schizophrenia:
An animal model investigating the potential role of nitric oxide
The dissertation will be publically defended on Wednesday 14th December at 09.00, Room 2118, Arvid Wallgrens Backe, hus 2, Göteborg.

For further information contact: Caroline Wass, Pharmacologist, telephone: +46 (0)31 786 3420, +46 (0)70 498 4958, email: caroline.wass@pharm.gu.se Supervisors: Associate professor Lennart Svensson, telephone: +46 (0)31 786 3402, email: lennart.svensson@pharm.gu.se Professor Jörgen Engel, telephone: +46 (0)31 786 3416, email: jorgen.engel@pharm.gu.se Professor Trevor Archer, telephone: +46 (0)31 786 4694, email: trevor.archer@psy.gu.se Dr. Daniel Klamer PhD, telephone: +46 (0)31 786 3403, email: daniel.klamer@pharm.gu.se

Pressofficer: Elin Lindström Claessen; elin.lindstrom@sahlgrenska.gu.se;
+46-70 829 43 03

Elin Lindström Claessen | idw
Further information:
http://www.vr.se

Further reports about: Oxide Wass function nitric schizophrenia

More articles from Life Sciences:

nachricht Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View
22.06.2018 | University of Sussex

nachricht New cellular pathway helps explain how inflammation leads to artery disease
22.06.2018 | Cedars-Sinai Medical Center

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>