Diabetes is a metabolic condition in which the body does not form sufficient quantities of insulin or in which the insulin that is formed does not have sufficient effect. The most common form of the disease is type 2 diabetes, which is the variant that adults can develop.
Most people who develop type 2 diabetes are overweight. Fat can accumulate in the muscles and liver of an obese person, leading to cell damage that in turn leads to a defect in the signalling from insulin. The result is an increase in the blood sugar level, and diabetes develops.
"The faulty storage of fat in the muscle cells interferes with the signal from the insulin that should stimulate increased absorption of sugar by the cells. The fat is stored in the cells in the form of fat droplets, and we have studied in detail how these are formed and how they grow. This has enabled us to show how the insulin signal is disrupted", says Professor Sven Olof Olofsson, director of the Wallenberg Laboratory at the Sahlgrenska Academy.
The research project used several advanced microscopy techniques to study lipid droplets in cultured muscle cells. It became clear that the lipid droplets merged with each other inside the cell by a process that involved a protein known as "SNAP23". This protein has another, independent, function - that of passing the insulin signal onwards into the cell.
"It appears that the SNAP23 is being 'stolen' from the insulin signalling process when the cell starts to pack fat, and this causes the defect that subsequently leads to diabetes. If we can find out more about how this works in detail, we may be able to influence the process and protect patients from developing diabetes", says Pontus Boström, PhD student at the Sahlgrenska Academy.
Further research will be necessary before the results can be tested in patients.
The results will be published in the next issue of the journal Nature Cell Biology.Journal: Nature Cell Biology
Authors: Pontus Boström, Linda Andersson, Mikale Rutberg, Jeanna Perman, Ulf Lidberg, Bengt R. Johansson, Julia Fernandez-Rodriguez, Tommy Nilsson, Jan Borén and Sven-Olof Olofsson.
For more information, contact: Professor Sven Olof Olofsson, telephone: +46 31 342 1956, e-mail: email@example.com Dr. Pontus Boström, telephone: +46 31 342 2947, e-mail: firstname.lastname@example.org
Elin Lindström Claessen | idw
World’s Largest Study on Allergic Rhinitis Reveals new Risk Genes
17.07.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Plant mothers talk to their embryos via the hormone auxin
17.07.2018 | Institute of Science and Technology Austria
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
17.07.2018 | Information Technology
17.07.2018 | Materials Sciences
17.07.2018 | Power and Electrical Engineering