The genes were found by Dr. Vasiliki Theodorou in the research group of Dr. John Hilkens in an exhaustive screen for new oncogenes by using mouse mammary tumor virus-based insertional mutagenesis, an existing technology that obtained a new impuls as a result of the recent completion of the mouse genome sequence. The technology is based on the property of retroviruses to incorporate their DNA in the genome of the host cell as part of their live cycle. The incorporated DNA behaves as a mutagen and affects the activity of adjacent genes or interrupts the coding sequence of a host cell gene. If the affected gene is an oncogene, the integration can lead to tumor development.
Because the genetic code is known the integration site of the viral DNA can be exactly be located. Subsequently, the gene that is affected by the inserted virus can be identified. It is the first time that so many genes were identified in this way.
Theodorou and collegues looked for breast cancer genes in a mouse model. Breast cancer research in mice provide us more insight in development of human breast cancer and aid reseachers in the development of new therapies.
Frederique Melman | alfa
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Health and Medicine
16.11.2018 | Life Sciences
16.11.2018 | Life Sciences