These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research published in the May issue of the Journal of Bacteriology, and highlighted in Nature Reviews/Microbiology.
B. cenocepacia is a multi-drug resistant microorganism that lives in damp or wet places and causes rot in plants such as onions. While it rarely causes infection in healthy people, it can be fatal for people with cystic fibrosis (CF), an inherited disease where the lungs become clogged with thick mucus, often leading to chronic respiratory infections.
The team of researchers has identified a weakness in the armour that protects the B. cenocepacia bacterium from the effects of antibiotics. They hypothesize that preventing the synthesis of a key sugar required for this armour, 4-amino-4-deoxy-L-arabinose (Ara4N), may lead to a susceptibility within the cell membrane to antibiotics.
"We are very excited with these findings, as they will let us come up with novel molecules to disrupt the making of Ara4N," says Valvano. "These molecules could then be tested as novel antibiotics." Valvano is a Professor and Chair of the Department of Microbiology and Immunology, a Canada Research Chair in Infectious Diseases and Microbial Pathogenesis, and leader of the Infectious Diseases Research Group at the Siebens-Drake Research Institute. He is available for interviews.
The research was funded through the Canadian Cystic Fibrosis Foundation and the Canadian Institutes of Health Research (CIHR). "We're delighted by this news," says Cathleen Morrison, CEO of the Canadian Cystic Fibrosis Foundation. "The possibility of a life-saving antibiotic to fight B. cenocepacia is tremendously encouraging to adults and children who have cystic fibrosis."
Dr. Bhagirath Singh, Scientific Director of the CIHR Institute of Infection and Immunity, says "This discovery provides new hope for the eradication of these bugs from cystic fibrosis patients and to improve their quality of life by developing new treatments."
A molecular switch may serve as new target point for cancer and diabetes therapies
08.08.2018 | Forschungsverbund Berlin e.V.
Potential indicator for the early detection of dementias
08.08.2018 | Universität Basel
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz- Forschungsinstitut für Molekulare Pharmakologie (FMP) in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases. The results of the study have just been published in the prestigious scientific journal 'Molecular Cell'.
Cell growth and cell differentiation as well as the release and efficacy of hormones such as insulin depend on the presence of lipids. Lipids are small...
You seem to be standing in the plasma vessel looking around: Where otherwise plasmas with temperatures of several million degrees are being investigated, with...
A magneto-plasmonic nanoscale router and a high-contrast magneto-plasmonic disk modulator controlled by external magnetic fields
Plasmonic waveguides open the possibility to develop dramatically miniaturized optical devices and provide a promising route towards the next-generation of...
The first unambiguous observation of a radioactive molecule, 26AlF, was made in the ancient nova-like object CK Vul (or Nova Vul 1670), which - most likely - is a stellar-merger remnant. The eruption of the object was observed between 1670-1672 in Europe. The interest in this object has been recently rejuvenated by the discovery of molecular gas of a very peculiar isotopic composition in the remnant.
The finding was announced by an international research team led by Tomasz Kamiński (CfA), including Karl Menten (MPIfR Bonn).
The variable star CK Vulpeculae (CK Vul) is known as the location of a stellar outbreak, a nova, which was observed by European astronomers in the 17th century...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
08.08.2018 | Materials Sciences
08.08.2018 | Physics and Astronomy
08.08.2018 | Materials Sciences