Several T cell subsets with immunosuppressive functions have been reported to demonstrate their suppressive capabilities to the acquired immune system in animal autoimmune disease models. Among them, CD4+ T cells constitutively expressing CD25, termed CD4+CD25+ regulatory (Treg) cells, are considered to be the major controllers of autoreactive T cells, thus maintaining immunological self-tolerance. The human equivalent was identified in CD4+ T cells expressing only high levels of CD25 (CD4+CD25high regulatory T (Treg) cells).
This study examined the number and function of CD4+CD25high Treg cells in PV. Peripheral blood mononuclear cells were prepared from PV patients as well as normal and disease control volunteers, and the frequency and phenotypes of T cells were determined by flow cytometry. CD4+CD25+ and CD4+CD25- T cells isolated from peripheral blood mononuclear cells of PV patients and normal controls were subjected to real-time semiquantitative RT-PCR for the expression of Foxp3 gene.
The proportion of T cells in all PV patients was severely reduced, approximately ten times less than in controls. These observations were further confirmed by both diminished gene and protein expression of Foxp3 in the CD4+CD25+ T cell population in PV patients. However, additional studies are needed to further clarify the role of T cells in the pathogenesis of PV.
Carla Holmes | alfa
Protein interaction helps Yersinia cause disease
21.08.2018 | Schwedischer Forschungsrat - The Swedish Research Council
Nanobot pumps destroy nerve agents
21.08.2018 | American Chemical Society
There are currently great hopes for solid-state batteries. They contain no liquid parts that could leak or catch fire. For this reason, they do not require cooling and are considered to be much safer, more reliable, and longer lasting than traditional lithium-ion batteries. Jülich scientists have now introduced a new concept that allows currents up to ten times greater during charging and discharging than previously described in the literature. The improvement was achieved by a “clever” choice of materials with a focus on consistently good compatibility. All components were made from phosphate compounds, which are well matched both chemically and mechanically.
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Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
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Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
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