A total of 293 patients with plaque psoriasis, 82 patients with psoriasis guttata and 202 control subjects were enrolled in this study. Investigations focused on 3 polymorphisms in retinoid X receptors RXRA and RXRB gene associations. The possible association of their variability with psoriasis was investigated.
A marginally significant increase in AA allelic frequency of the RXRA A39526AA polymorphism in plaque psoriatic men compared to healthy ones was proven. In women with psoriasis guttata, a higher risk for genotypes AA and TT in the RXRB 3'+140A/T polymorphism compared to healthy women was identified. The genotypes A/A and AA/AA were more frequent in plaque psoriasis patients with a positive family history of psoriasis compared to patients with a negative family history of psoriasis. The A/A genotype was more frequent in patients with plaque psoriasis and repeated tonsillitis/tonsillectomy. In the RXRB polymorphism, no genotype TT was observed in patients with psoriasis guttata with a positive personal history of repeated tonsillitis.
Accordingly, these two RXR polymorphisms seem to be susceptibility genes for psoriasis. This knowledge contributes to improving the results of psoriasis therapy using a pharmacogenomic approach.
Carla Holmes | alfa
Microscope measures muscle weakness
16.11.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
Good preparation is half the digestion
16.11.2018 | Max-Planck-Institut für Stoffwechselforschung
Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...
Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...
Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences