Each year 170,000 people around the world die of this type of meningitis, according to the World Health Organization, WHO. Bacterial meningitis, as the disease is called, can even spark epidemics: in Africa 250,000 people were affected in a matter of weeks in the late 1990s. Without treatment, mortality among those who contract the disease is 85-90 percent, with treatment some 10-15 percent. Patients also run a high risk of serious disability after recovery.
Only humans are susceptible to infection from meningococci. In its modeling system Ann-Beth Jonsson’s research team therefore used mice that produce the human receptor that the bacteria bind to. Marking the bacteria to emit light, the scientists used cameras to monitor their activities in the living mice during the course of the disease.
“The bacteria are almost knocked out by the immune defense system, but then they resurge, this time with alterations in the surface protein. What’s more, we discovered that the bacteria aggregate in the thyroid and can impact hormone production during the infection,” says Ann-Beth Jonsson.
The study also shows that bacteria that lack a certain adhesin (the protein that the bacteria cells use to adhere to the receptors) could not attach to mucous linings.
Thanks to the new system the research team has developed, it is now possible to rapidly and effectively monitor the function of various vaccine candidates and new drugs, obviating the numerous costly and time-consuming tests that have been necessary until now. At the same time, the system provides a clear picture of the process of infection.
“With these findings as tools, we can continue to study the course of the disease and test vaccines on living organisms. Moreover we will be able to find new strategies for improving the prognoses for those who are affected by meningococcus disorders,” says Ann-Beth Jonsson.
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For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
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Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
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Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
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Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
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12.07.2018 | Event News
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19.07.2018 | Social Sciences
18.07.2018 | Life Sciences
18.07.2018 | Materials Sciences