A new type of protein discovered by Queen’s University researchers may be useful in developing treatments for antibiotic-resistant bacteria, such as those that cause food poisoning and typhoid.
By solving the structure and activity of the protein – called YihE or RdoA – a team of professors and students from the departments of Biochemistry and Microbiology & Immunology has opened up possibilities for new drug development.
“Our group is the first to solve the structure and to begin to understand the function of this particular protein,” says Dr. Nancy Martin (Microbiology & Immunology), who coordinated the study with Dr. Zongchao Jia (Biochemistry). “It turns out to be a potentially good target in a wide range of bacteria that cause infectious diseases.” Because of the increasing number of antibiotic-resistant strains of many different types of bacteria, such as salmonella, she notes, new approaches to antibiotic therapy are needed.
The Queen’s findings are published in the on-line edition of the journal Molecular Microbiology. Also on the team, from Biochemistry, are PhD student Jimin Zheng and post-doctoral fellow Vinay Singh; and Microbiology & Immunology Master’s student Chunhua He.
The group is studying sensory pathways used by bacteria that enter our bodies and move from the stomach into the gastro-intestinal tract. “If we can block the sensory pathway, then the bacteria can’t adapt to that change in their environment, and won’t be able to infect,” says Dr. Martin.
In North America, the people treated for food poisoning with drugs tend to be elderly or “immune compromised” where there is a need for antibiotics to clear the infection. Since the organism that causes salmonellosis is related to that responsible for typhoid fever – a huge problem in less developed countries – the model being developed at Queen’s could potentially be a target for treating typhoid as well. The underlying goal is to control, if not clear, the infection.
“It’s basic science that we are doing, but we’re using that as a foundation for trying to develop approaches that will have positive impacts on human health,” says Dr. Martin.
Nancy Dorrance | EurekAlert!
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
19.07.2018 | Earth Sciences
19.07.2018 | Power and Electrical Engineering
19.07.2018 | Materials Sciences