Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Taking heart failure to the MAT1

07.02.2007
A gene called ménage-à-trois 1, or MAT1, plays a crucial role in the function of a master switch for production of energy in the heart cell -- a finding that has important implications for understanding and maybe even treating heart failure, said researchers from Baylor College of Medicine and other institutions in a report published in today's issue of the journal Cell Metabolism.

When Dr. Michael Schneider, professor of medicine, molecular & cellular biology, and molecular physiology & biophysics at BCM, and his colleagues studied infant mice that lacked this gene in their heart muscle cells, "We found that the hearts grew normally. This was surprising, in view of some postulated functions of MAT1. But when the animals reached five weeks of age, they began to succumb to catastrophic heart failure, and all of them were dead by two months."

Using "gene chip" technology, the researchers looked for abnormal patterns of gene expression in hearts from which the MAT1 gene was deleted. They found that genes controlling energy production in cells were particularly affected and that the cells had correspondingly low levels of the proteins required for energy production. The mitochondria -- the cell's energy factories -- were defective.

Further research showed that a particular protein called peroxisome proliferator-activated receptor-1 coactivator, or PGC-1, which is a known master regulator of energy production by cells, did not function in cells that lacked MAT1. Even when the scientists artificially increased the amount of PGC-1 in the cells, its function was decreased if there was no MAT1.

... more about:
»MAT1 »PGC-1 »failure

Ultimately, the investigators proved that MAT1 binds to PGC-1 and forms a physical complex with it, providing a direct biochemical explanation for the ability of MAT1 to serve as an essential partner to PGC-1, facilitating its role in regulating cell metabolism.

In fact, two forms of PGC-1 exist — alpha and beta — both of which have been reported by other groups to be vital to the heart. Both forms of PGC-1 were shown by Schneider's team to depend highly on MAT1 and to turn on the ordinarily responsive genes for energy production in heart tissue.

"One of the problems in failing hearts is that energy production is deficient," said Schneider. "Drugs that act on the PPARs (peroxisome proliferator activated receptors) and other nuclear receptors to promote better metabolism are a very active area of study. Finding an essential partner of PGC-1 alpha and beta that enables them to switch genes on via these receptors should be helpful in that kind of work."

Ross Tomlin | EurekAlert!
Further information:
http://www.bcm.edu

Further reports about: MAT1 PGC-1 failure

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>