A research team led by Prof. Claude Perreault, Université de Montréal, is announcing a major discovery in Genomics. This will generate a fundamental impact on the treatment of blood cancers (leukemias and lymphomes) by means of peripheral blood T-cell grafts.
Peripheral blood stem-cell grafts from immunologically-matched donors are still the best way to treat or cure patients with certain leukemias and lymphomas. In Canada alone, 10 000 people have benefited from this therapy. However, this type of graft is risky because of a major potential complication: "graft-versus-host disease" (GVHD). GVHD is a rejection of recipient tissues by the donor's T cells that see their new host as ‘non-self'. As many as 60% of recipients develop GVHD. In the best-case GVHD scenario, the disease markedly diminishes the patient's quality of life. In the most severe cases, GVHD may cause death. Because of the GVHD risk, graft of donor T cells can only be proposed to a small number of patients having leukemia or lymphoma. And until now, no reliable prediction could be made to determine if a recipient would be likely to incur GVHD or not. Published this week in the Public Library of Science Medicine (PLoS Medicine) this discovery provides a sure way of identifying cells that will cause GVHD.
Today's announced discovery opens the way to a reliable test to determine whether or not the cells of a donor will likely cause GVHD or not in the recipient, if the graft is performed. Creating a predictive test based on this discovery will have a considerable impact on the future of patients.
"A predictive test that will identify dangerous and non-dangerous donors will allow physicians to choose the best donor," explains Dr Perreault. "If no ‘non-dangerous donor' is found, then a physician can give the recipient a more intensive immuno-suppressive treatment to prevent GVHD. This opens the door to hematopoietic cell transplant personalized medicine."
"In this research, the special combinations of clinical design, advanced cell-sorting technology, large-scale gene expression profiling, and novel statistically-supported outcome-predictive computational analyses have produced together a very effective systems biology approach," says Biosystemix co-founder Dr. Larry Greller. "We are excited by the practicality and potential medical utility of these results, and look forward to their continuing validation in larger contexts," says Biosystemix co-founder Dr. Roland Somogyi.
For Génome Québec, it is a truly dramatic breakthrough that will not only improve and save lives, but also highlights the importance of backing and promoting knowledge in Genomics. According to Paul L'Archevêque, President and CEO of Génome Québec, "The researchers have done tremendous work! Clinical work will be transformed and moreover, first-line needs will be met in hospitals, from bench to bedside.".
The study involved 13 senior researchers and 50 patients suffering from haematological cancers and their respective immunologically-matched sibling donors. The patients were from the Maisonneuve-Rosemont hospital in Montreal. Statistical analysis and mathematical outcome-predictive modeling of these complex data were provided by the biotech company Biosystemix Ltd. In the coming months, the discovery will be extended in larger test phases to other hospitals in Canada and the US.
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences