Roslin scientists and colleagues at the Burnham Institute for Medical Research in La Jolla, California, are studying how enzymes control production of calcium phosphate in the skeleton. Up to 10 percent of the total bone mass is renewed by calcification every year - but elsewhere in the body calcification is a problem that can lead to kidney stones, hardened arteries or osteoarthritis. The research will help to understand why calcification normally only occurs in bone, and how this is controlled.
The identification of the role of the enzyme PHOSPHO1 in bone calcification at Roslin, a sponsored institute of the Biotechnology and Biological Sciences Research Council (BBSRC), has directly led to the £1M from the US National Institute of Health to take the research forward.
PHOSPHO1 plays a key role in healthy bone development by producing inorganic phosphate, as Dr Colin Farquharson from the Roslin Institute explained: "This is one of the first steps in a process where mineral crystals of calcium phosphate are produced and laid down in precise amounts within the bone's scaffolding."
The joint research project will be investigating how PHOSPHO1 interacts with other enzymes to control skeleton calcification and limit calcium production in other parts of the body.
Dr Farquharson explained: "By blocking PHOSPHO1 production, we can reduce initial mineralisation, or calcification, by up to 70 percent. But there must be other enzymes and pathways involved, to account for the remaining level of mineralisation."
Professor Julia Goodfellow, Chief Executive of BBSRC, said: "This US funded project shows the research at Roslin Institute is recognised internationally. This research will provide fundamental insights into the mechanisms of normal bone mineralisation, which could lead to therapeutic strategies for disorders such as osteoarthritis, osteoporosis and hardened arteries."
Scientists uncover the role of a protein in production & survival of myelin-forming cells
19.07.2018 | Advanced Science Research Center, GC/CUNY
NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences