Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New evidence that stem cells contain immortal DNA

26.06.2006
EuroStemCell scientists at the Pasteur Institute in Paris have demonstrated one of the body’s most sophisticated ways of regulating the genetic material of stem cells. Their findings, published in Nature Cell Biology(*), show for the first time the mechanism that adult muscle stem cells use to protect their DNA from mutations. Understanding this has important implications for cancer research, the study of gene regulation, and ultimately growing stem cells of therapeutic potential in the laboratory.

When a cell divides, its DNA is duplicated and each resulting daughter cell inherits one copy of the DNA. Over time, errors arising during the duplication process can lead to mutations and cause cancers. Using sophisticated approaches including video imaging the Pasteur team show that stem cells retain the original DNA strands. Their findings also represent the best visual evidence yet for immortal DNA (**) - a controversial theory first proposed more than 3 decades ago.

A stem cell can produce two different daughter cells when it divides in the body – another stem cell and a specialised cell that will contribute to the tissue. This is called “asymmetric division” and helps stem cells regulate their numbers and retain their capacity to regenerate tissue throughout the life of an organism. According to the immortal DNA hypothesis, when a stem cell divides, only the specialised cell inherits the imperfect copied DNA. The stem cell retains the original “immortal” DNA strand.

Leading the Pasteur team, Shahragim Tajbakhsh says “the immortal DNA theory has captured the imagination of many scientists for decades, but it has been particularly difficult to prove. By tracking skeletal muscle stem cells from mouse muscle fibres, both in vivo and in the dish, we have shown that the DNA strands of the double helix are not equivalent, and we have linked this phenomenon with the general asymmetry apparatus of the dividing cell.”

He adds “this is an exciting finding, as it seems to defy one of the basic rules of cell biology and genetics: that genetic material is distributed randomly. It appears that the cellular machinery distinguishes old from new when it comes to DNA, and it may use this distinction to protect the body from mutations and cancer. It is also possible that this mechanism is used to silence gene expression in the stem cell.”

Kate Doherty | alfa
Further information:
http://www.eurostemcell.org

More articles from Life Sciences:

nachricht Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover

nachricht First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>