Led by Dr. Janet Smith, this study offers important insights into the evolution of kinases, which are enzymes involved in cell communication pathways. Approximately 2.5% of human genes code for protein kinases, and mutations in many of these genes are at the root of a range of human diseases. Dictyostelium is a widely used model organism for scientific study, as it is remarkably similar to mammalian cells, and it is amenable to a range of laboratory techniques.
To solve the kinome of Dictyostelium, Dr. Smith and her colleagues at Boston Biomedical utilized the power of bioinformatics, a cutting edge scientific technique which employs databases and computer algorithms to allow researchers to gain information and compile data about genes and kinases in a fast and efficient way, which can be very useful for drug discovery and development.
According to Dr. Smith, Dictyostelium provides a simple model in which to study conserved cellular processes, and illuminates a period in the evolutionary history of the metazoa after the divergence of the plants but before that of the fungi. “Our findings document the impressive evolutionary creativity of the Dictyostelium kinome- a large portion of the kinases are unique to Dictyostelium, and are probably involved in unique aspects of this organism’s biology,” said Dr. Smith.
But conservation is also a major theme. By comparing the Dictyostelium kinome with those of other organisms, the authors find 46 types of kinases that appear to be conserved in all organisms, and are likely to be involved in fundamental cellular processes. “We believe this study will be very useful to researchers who are studying cell communication pathways in other organisms, including vertebrates, by demonstrating what aspects of signaling are conserved, and revealing opportunities to use Dictyostelium to understand important human proteins.”
Boston Biomedical Research Institute is a not-for-profit institution dedicated to the understanding, treatment and prevention of specific human diseases including cancer, Alzheimer’s disease, muscular dystrophy, diabetes and conditions such as obesity and reproductive health problems.
Climate Impact Research in Hannover: Small Plants against Large Waves
17.08.2018 | Leibniz Universität Hannover
First transcription atlas of all wheat genes expands prospects for research and cultivation
17.08.2018 | Leibniz-Institut für Pflanzengenetik und Kulturpflanzenforschung
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
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17.08.2018 | Life Sciences