The thin, single-cell boundary where a tumor meets normal tissue is the most dangerous part of a cancer according to a new study by scientists at Washington University School of Medicine in St. Louis. The researchers found that tumor cells bordering normal tissue receive signals that tell them to wander away from the tumor, allowing the cancer cells to establish deadly metastatic tumors elsewhere in the body.
The researchers say their discovery demonstrates the importance of the tumors environment and shows more precisely how the metastatic process occurs and might be stopped. Their study appears in the January 10 issue of Developmental Cell.
"What actually kills in cancer is not the primary tumor--its metastasis," says senior author Ross L. Cagan, Ph.D., associate professor of molecular biology and pharmacology and a researcher with the Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital. "You cant study that in a laboratory dish. You have to look at the tumor cells in their natural environment--surrounded by normal tissues."
Gwen Ericson | EurekAlert!
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Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
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