Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Flavonoids may inhibit prostate cancer

21.10.2005


Eating a diet rich in fruits and vegetables could be a good defense against prostate cancer, according to a Case Western Reserve University study published in the October online issue of the Federation of American Societies for Experimental Biology Journal.



Previous studies have suggested that increased intake of flavonoids which are common in fruits and vegetables may be associated with a reduced risk of prostate cancer, according to Sanjay Gupta, Ph.D., an assistant professor in the Case School of Medicine Department of Urology. Apigenin is a plant flavonoid commonly found in fruits and vegetables, as well as herbs, including chamomile, lemon balm, perilla and parsley.

"Flavonoids have aroused considerable interest recently because of their potential beneficial effects on human health, and have reported to have antiviral, anti-allergic, antiplatelet, anti-inflammatory, antitumor and antioxidant activities," Gupta said. "Apigenin has been shown to lower inflammation and oxidative stress, and exerts growth inhibitory effects on cancer cells."


In the study, Gupta and his team orally fed apigenin to mice two weeks before implanting a prostate tumor, then continuing the feedings for eight weeks. In a second protocol, apigenin was fed to mice two weeks after tumor implantation.

The first protocol mimicked prevention regimens, while the second followed therapeutic regimens for cancer.

In both cases, the apigenin slowed tumor growth and did not appear to cause any adverse side effects such as weight gain or changes in diet, which is common in patients who undergo chemotherapy treatments.

Apigenin also resulted in a decrease in IGF-1 (insulin-like growth factor) levels, which are associated with an increased risk of breast, prostate, colorectal and lung cancers, as well as a significant increase in IGFBP-3 (insulin-like growth factor binding protein) levels, which is associated with a decreased risk for these same cancers. The effect impacts the survival of prostate cancer by triggering cell self-destruction.

"Apigenin may prove useful in the prevention and therapy of prostate cancer by shutting off the IGF signaling that leads to prostate cancer cell growth and/or development," Gupta said.

"Our findings suggest that apigenin could be developed as a promising agent against prostate cancer," Gupta said. "The next step is to evaluate apigenin action on other molecular pathways which have relevance to prostate cancer."

Gupta’s colleagues contributing to the study included Sanjeev Shukla, Ph.D.; Gregory T. MacLennan, M.D.; Pingfu Fu, Ph.D.; Martin I. Resnick, M.D.; from Case Western Reserve University and University Hospitals of Cleveland, and Anil Mishra, Ph.D. from University of Pittsburgh.

George Stamatis | EurekAlert!
Further information:
http://www.case.edu

More articles from Life Sciences:

nachricht NYSCF researchers develop novel bioengineering technique for personalized bone grafts
18.07.2018 | New York Stem Cell Foundation

nachricht Pollen taxi for bacteria
18.07.2018 | Technische Universität München

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

Im Focus: Chemical reactions in the light of ultrashort X-ray pulses from free-electron lasers

Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.

Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

Machine-learning predicted a superhard and high-energy-density tungsten nitride

18.07.2018 | Materials Sciences

NYSCF researchers develop novel bioengineering technique for personalized bone grafts

18.07.2018 | Life Sciences

Why might reading make myopic?

18.07.2018 | Health and Medicine

VideoLinks
Science & Research
Overview of more VideoLinks >>>