Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCLA/NIH scientists block viruses from entering cells

12.09.2005


New approach could help fight HIV, herpes, flu and antibiotic-resistant bacteria



FINDINGS: First identified more than 20 years ago at UCLA, defensins are peptides naturally produced by the immune system to ward off viruses. However, it was unclear how defensins worked. Now UCLA and NIH scientists have discovered that a specific defensin called retrocyclin-2 (RC2) binds to carbohydrate-containing proteins in cell membranes. This mechanism erects molecular barricades that block attacking viruses from entering and infecting the cell. RC2 stops the virus in its tracks, preventing it from replicating and spreading throughout the body.

IMPACT: The NIH/UCLA team used human and animal cell lines to demonstrate RC2’s protection against the influenza virus. The team’s earlier studies suggest that RC2 offers great promise as the lead compound for new antiviral drugs to fight off HIV and herpes, as well. Unlike antibodies, however, defensins are not pathogen specific. In addition to blocking viruses, RC2 also kills several bacteria that are highly resistant to conventional antibiotics.


AUTHORS: Dr. Robert Lehrer, Distinguished Professor of Medicine at the David Geffen School of Medicine at UCLA, is available for interviews. Leonid Chernomordik, Ph.D., section chief of Membrane Biology, Laboratory of Cellular and Molecular Biophysics, led the NIH team.

Rachel Champeau | EurekAlert!
Further information:
http://www.mednet.ucla.edu

More articles from Life Sciences:

nachricht Staying in Shape
16.08.2018 | Max-Planck-Institut für molekulare Zellbiologie und Genetik

nachricht Chips, light and coding moves the front line in beating bacteria
16.08.2018 | Okinawa Institute of Science and Technology (OIST) Graduate University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Staying in Shape

16.08.2018 | Life Sciences

Diving robots find Antarctic seas exhale surprising amounts of carbon dioxide in winter

16.08.2018 | Earth Sciences

Protein droplets keep neurons at the ready and immune system in balance

16.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>