Because atherosclerotic plaque typically builds up without symptoms and leads to more than 1 million deaths in America each year, the search is on to develop early detection devices that will enable physicians to offer treatment before the disease progresses to advanced stages.
Now, in a study involving laboratory rabbits, a device that stimulates, collects and measures light emissions from body tissues has been able to detect the presence of inflammatory cells that are associated with critical atherosclerotic plaques in humans – plaques that are vulnerable to rupture. The study is described in the August 2005 issue of the journal Atherosclerosis.
Recent atherosclerosis research has found that the composition of plaque and its "vulnerability" to rupture may be more significant than the degree of arterial blockage as a precursor to heart attack and stroke. The lining (intima) of a normal artery consists of several thin layers of cells and connective tissue. Segments containing stable atherosclerotic plaque become thickened with collagen while sections of vulnerable plaque are infiltrated by macrophages. In humans, the inflammatory process weakens the plaques thin, fibrous cap, often leading to rupture of the plaque and blockage of blood vessels.
Sandy Van | EurekAlert!
Happy hour for time-resolved crystallography
17.09.2019 | Max-Planck-Institut für Struktur und Dynamik der Materie
Too much of a good thing: overactive immune cells trigger inflammation
16.09.2019 | Universität Basel
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.
The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.
At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.
Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...
Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....
Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.
This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.
Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.
If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...
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