Caterpillars are bleeding defensive! Insects are known to lack an antibody-mediated immune response, and research in caterpillars has recently shown that, instead, they produce protective proteins in response to bacterial infection. The pattern recognition receptors (PRR) and antibacterial effectors produced at a first infection still function to protect against a repeated challenge. These results raise important issues in insect research which will be reported by Dr. Ioannis Eleftherianos at the Society of Experimental Biology Annual Meeting at the Universitat Autonoma de Barcelona on Wednesday 13th of July.
After being fed on a diet of antibiotics, hawkmoth (Manduca sexta) caterpillars were infected by non-pathogenic bacteria (E. coli), followed by exposure to a second, but lethal insect pathogen (Photorhabdus). Investigation of their blood then showed that antibacterial peptides were being produced by the so-called ‘fat-body’, an organ specialised in protein production. These proteins appear to be able to persist from the initial benign E. coli infection and then confer resistance against the second, usually lethal, infection by the pathogen. Using RNAi techniques workers at the University of Bath have shown that several different proteins can confer this protective effect against subsequent infections.
Micro-organisms such as bacteria, fungi and nematodes are often used as biocontrol agents against insects. It had always been assumed that insects in the field would be naïve to such control agents but these results raise the possibility that control with one pathogen may confer resistance to another. Most experiments on insect immunity are conducted in the laboratory on insects often fed on antibiotic containing diet so these results suggest that the immune response of insect constantly exposed to pathogens in the field may be very different from all the work described in the laboratory. This raises new challenges for the field and places into question the relevance of laboratory based studies on immunity.
Diana van Gent | alfa
Seeing on the Quick: New Insights into Active Vision in the Brain
15.08.2018 | Eberhard Karls Universität Tübingen
New Approach to Treating Chronic Itch
15.08.2018 | Universität Zürich
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy