Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Non-invasive and invasive breast cancers share the same genetic mutations

08.03.2005


Women diagnosed with early stage, non–invasive breast cancer who carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer, may benefit from high risk treatment, Yale researchers report in the February 23 issue of Journal of the American Medical Association.



The inherited breast/ovarian cancer genes are BRCA1 and BRCA2, which are associated with an increased risk of breast and/or ovarian cancer. The results are part of a five–year study of a common form of early stage breast cancer called ductal carcinoma in situ (DCIS). Led by Elizabeth B. Claus, M.D., associate professor in the Department of Epidemiology and Public Health (EPH) at Yale School of Medicine, the Yale team examined genetic and environmental risk factors for the development of DCIS. They genetically tested 369 women with DCIS for alterations in BRCA1 and BRCA2. "We found that 0.8 percent of these women had disease–associated mutations in BRCA1, while 2.4 percent had such mutations in BRCA2," said Claus. "These numbers are similar to those reported for women with more advanced breast cancer."

Claus said women with mutations were more likely to be diagnosed with DCIS at a young age, to have also been diagnosed with ovarian cancer and to have a first degree family member (mother, sister or daughter) diagnosed with breast cancer, particularly at a young age. "This study highlights the fact that although DCIS is generally associated with a favorable clinical prognosis, it is important to consider women diagnosed with DCIS and with an appropriate personal or family history of breast and ovarian cancer, as potential members of the inherited breast/ovarian cancer syndromes defined by BRCA1 and BRCA2," said Claus. "As such, this subset of DCIS patients should be screened and followed according to high–risk protocols as are similar women diagnosed with invasive breast cancer."

Karen N. Peart | EurekAlert!
Further information:
http://www.yale.edu

More articles from Life Sciences:

nachricht Seeing on the Quick: New Insights into Active Vision in the Brain
15.08.2018 | Eberhard Karls Universität Tübingen

nachricht New Approach to Treating Chronic Itch
15.08.2018 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>